Kinetic Study on the Production of Butirosin A by Bacillus vitellinus : Studies on the Application of Fermentation Kinetics(VI)

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概要

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• A kinetic study was made on the fermentation for the production of butirosin A by a butirosin A-resistant mutant BA-44R derived from Bacillus vitellinus Z-1159. A butirosin A-sensitive mutant BA-44S which was a natural revertant of strain BA-44R was observed to exist in the fermented broth.Based on the theory of fermentation kinetics which we reported on previously, general equations for growth rate and production rate in a mixed culture of a product-resistant strain and a product-sensitive strain are presented by introducting a newly defined inhibition rate constant, K_i.The effects of fermentation conditions on microbial cell growth and product formation were estimated theoretically by substituting the fermentation characteristic values of the two strains into the general equations. The results of the estimation were successfully applied to the increase of butirosin A production.

• 公益社団法人日本生物工学会の論文
• 1978-10-25

著者

• Kono Takehiko

  Microbiological Research Laboratories Central Research Division Takada Chemical Industries Ltd.

• Asai Tsunetomo

  Microbiological Research Laboratories Central Research Division Takada Chemical Industories Ltd.

• FUKUDA HIDEKI

  Microbiolobical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.,

• Fukuda Hideki

  Microbiolobical Research Laboratories Central Research Division Takeda Chemical Industries Ltd.

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• Kinetic Study on the Production of D-Ribose by Bacillus sp. : Studies on the Application of Fermentation Kinetics (III)
• Kinetic Study on the Production of Butirosin A by Bacillus vitellinus : Studies on the Application of Fermentation Kinetics(VI)

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