Sustained reduction of serum cholesterol in low-dose 6-year simvastatin treatment with minimum side effects in 51,321 Japanese hypercholesterolemic patients - Implication of the J-LIT study, a large scale nationwide cohort study
スポンサーリンク
概要
- 論文の詳細を見る
The Japan Lipid Intervention Trial (J-LIT) study, a nationwide cohort study utilizing the clinical practice of general physicians, was designed to clarify the relationship between the incidence of coronary heart disease and serum lipid concentrations during simvastatin therapy, as well as the safety of the therapy, in a large number of Japanese hypercholesterolemic patients. All the enrolled patients were treated with simvastatin. The current study analyzed the lipid lowering effect and safety of the low-dose simvastatin therapy used in the J-LIT study. Open-labeled simvastatin was given to 51,321 patients at an initial dose of mostly 5 mg/day. After 6 months of the treatment, the average serum total cholesterol (TC) and low density lipoprotein-cholesterol concentrations in all the patients followed up were reduced by 18.3% and 26.0%, respectively, and that of high density lipoprotein-cholesterol increased 2.3% on average. These concentrations were well maintained throughout the 6-year treatment period. A minority of patients (1.4%) unexpectedly had a remarkable reduction in TC concentration by more than 40%. Hyper-responders, even to low-dose statin, were found for the first time in this large-scale and long-term investigation. Overall adverse drug reactions occurred in 3.3% of subjects during the 6-year treatment, the major events being hepatic and musculoskeletal disorders, of which the incidence was less than 1%. Low-dose simvastatin therapy of 5 mg/day effectively controlled the serum TC concentration by reducing it by approximately 20% on average in hypercholesterolemic Japanese patients, a reduction that corresponds to the effect of simvastatin 20 mg/day in Western studies. In addition, the low incidence of drug-related adverse events in this study may. be also related to the low dosage of simvastatin.
- 社団法人日本循環器学会の論文
- 2003-03-20
著者
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Kita Toru
Kyoto University Graduate School of Medicine
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Mabuchi Hiroshi
Kanazawa University Graduate School of Medicine
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Nakaya Noriaki
Nakaya Clinic
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Sasaki Jun
International University of Health and Welfare Graduate School
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Shimamoto Kazuaki
Sapporo Medical University School of Medicine
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Matsuzawa Y
Department Of Metabolic Medicine Graduate School Of Medicine Osaka University
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NAKAJIMA Norimichi
Nakajima Clinic
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Matsuzawa Yuji
Osaka University Graduate School of Medicine
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Matsuzaki Masunori
Kyoto University Graduate School of Medicine
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Nakaya Noriaki
Kyoto University Graduate School of Medicine
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Oikawa Shinichi
Kyoto University Graduate School of Medicine
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Saito Yasushi
Sapporo Medical University School of Medicine,Sapporoo,and lbaraki Christian University
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Itakura Hiroshige
Yamagichi University Graduate School of Medicine
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Sasaki Jun
Committee For Epidemiology And Clinical Management Of Atherosclerosis
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SASAKI Yasutsuna
National Cancer Center Hospital East
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Matsuzawa Yuji
山口大学 医学系研究科器官病態内科学
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Matsuzawa Yuji
Osaka Univ. Osaka Jpn
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