Large scale cohort study of the relationship between serum cholesterol concentration and coronary events with low-dose simvastatin therapy in Japanese patients with hypercholesterolemia and coronary heart disease - Secondary prevention cohort study of the

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概要

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• Hyperlipidemia is primarily implicated in the progression of coronary heart disease (CHD) and its treatment is essential for patients with a history of CHD. Statins such as simvastatin, the lipid-lowering agents, are well-known for their ability to normalize patient's serum lipid levels. The Japan Lipid Intervention Trial study of simvastatin is the first nationwide investigation of the relationship between serum lipid levels and the development of CHD in Japanese patients with hypercholesterolemia. Of 5,127 patients, exclusively with a history of documented CHD at enrollment, 4,673 were treated with open-labeled simvastatin at an initial dose of 5-10mg/day and were monitored for 6 years. The risk of coronary events tended to be higher in patients with a serum total cholesterol (TC) ≥240 mg/dl compared with total cholesterol ≤240 mg/dl. The concentration of low-density lipoprotein cholesterol (LDL-C) positively correlated and that of high-density lipoprotein cholesterol (HDL-C) inversely correlated with the risk of CHD. Each 10mg/dl decrease in LDL-C and each 10mg/dl increase in HDL-C concentration reduced the risk of CHD by 8.0% (95% confidence interval 3.8-12.0) and 28.3% (95% CI 13.9-40.3), respectively. A reasonable therapeutic strategy to reduce CHD progression in patients with prior CHD under low-dose statin treatment might be regulating the serum LDL-C concentration to at least ≤ 120 mg/dl and HDL-C ≥40 mg/dl, respectively.

• 社団法人日本循環器学会の論文
• 2002-11-20

著者

• Nakaya Noriaki

  Nakaya Clinic

• NAKAJIMA Norimichi

  Nakajima Clinic

• Mabuchi Hiroshi

  Kyoto University Graduate School of Medicine

• Kita Toru

  Yamaguchi University Graduate School of Medicine

• Matsuzaki Masunori

  Osaka University Graduate School of Medicine

• Matsuzawa Yuji

  Fussa General Hospital

• Nakaya Noriaki

  Nippon Medical School

• Oikawa Shinichi

  Chiba University Graduate School of Medicine

• Saito Yasushi

  International University Graduate School of Health and Welfare

• Sasaki Jun

  Sapporo Medical University School of Medicine

• Shimamoto Kazuaki

  Ibaraki Christian University

• Itakura Hiroshige

  Chairman of Central Committee

• Group.J-LIT Study

  Kyoto University Graduate School of Medicine

• Sasaki Jun

  Committee For Epidemiology And Clinical Management Of Atherosclerosis

• SASAKI Yasutsuna

  National Cancer Center Hospital East

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