LOW DOSES OF ENDOTHELIN-3 ELICIT ENDOTHELIUM DEPENDENT VASODILATION WHICH ACCOMPANIES WITH ELEVATION OF CYCLIC GMP
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概要
- 論文の詳細を見る
Low doses (10^<-16> -10^<-10> M) of endothelin-3 (ET-3) elicited continuous vasodilation of mesenteric arteries preconstricted with norepinephrine (NE) but not with KCl. In arteries perfused with Ca^<2+> free solution. ET-3 did not affect the perfusion pressure. In endothelium-denuded arteries preconstricted with NE, ET-3 significantly elevated the perfusion pressure in a dose-related manner. The levels of cyclic GMP and cyclic AMP from the intact arteries were significantly elevated by ET-3; the cyclic GMP elevasion disappeared with methylene blue. Following endothelium-denudation, cyclic GMP elevation was abolished, but cyclic AMP elevation was unaffected. Levels of 6-Keto-PGF_<1α> in the arteries were not changed appreciably by ET-3. These data indicate that the vasodilating effects of ET-3 depend on the presence of extracellular Ca^<2>+ and the existence of endothelium. They are accompanied by elevations of cyclic nucleotides and the elevation of cyclic GMP depends on the endothelium. It is possible that the vasodilating effects of low doses of ET-3 are associated with endothelium-derived relaxing factor.
- 社団法人日本循環器学会の論文
- 1991-06-20
著者
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Soma Masayoshi
Division Of Nephrology Hypertension And Endocrinology Department Of Medicine Nihon University School
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Soma Masayoshi
日本大学 医学部内科学系腎臓高血圧内分泌内科
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Soma Masayoshi
Second Department Of Internal Medicine Nihon University School Of Medicine
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Fukuda Noboru
Advanced Research Institute Of Science And Humanities Nihon University
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泉 洋一
日本大学 内科2
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Fukuda Noboru
日本大学 総合科学研究科
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Hatano Michinobu
The 2nd Dept, of Internal Medicine, Nihon Univ. School of Medicine (Dept. of Cardiology, Surugadai N
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Hatano Michinobu
The 2nd Department Of Internal Medicine Nihon University School Of Medicine
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WATANABE Yoshiyasu
Second Department of Internal Medicine, Nihon University School of Medicine
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Izumi Youichi
Department Of Cardiovascular Renal And Endocrine Medicines Research Center And Cardiovascular Functi
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IZUMI Yoichi
Div. of Cardiovascular Med. Nihon Univ. Sch. of Med
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Fukuda Noboru
The 2nd Department Of Internal Medicine Nihon University School Of Medicine
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Minato Masaya
Second Department Of Internal Medicine Nihon University School Of Medicine
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IZUMI YOICHI
The 2nd Department of Internal Medicine, Nihon University School of Medicine
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MINATO MASAYA
The 2nd Department of Internal Medicine, Nihon University School of Medicine
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SOMA MASAYOSHI
The 2nd Department of Internal Medicine, Nihon University School of Medicine
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WATANABE YOSHIYASU
The 2nd Department of Internal Medicine, Nihon University School of Medicine
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WATANABE MASASHI
The 2nd Department of Internal Medicine, Nihon University School of Medicine
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Hatano M
The 2nd Department Of Internal Medicine Nihon University School Of Medicine
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Hatano Michinobu
The 2nd Department Of Internal Medicine And Radiology Nihon University
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Honda Masanobu
The 2nd Department Of Internal Medicine Nihon University School Of Medicine
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Soma Masayoshi
Division Of Nephrology And Endocrinology Department Of Medicine Nihon University School Of Medicine
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Honda M
The 2nd Department Of Internal Medicine Nihon University School Of Medicine
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Watanabe Yoshiyasu
Second Department Of Internal Medicine Nihon University School Of Medicine
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Sato Mikano
Division Of General Medicine Department Of Internal Medicine Nihon University School Of Medicine
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Watanabe Masashi
The 2nd Department Of Internal Medicine Nihon University School Of Medicine
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Hatano M
The Second Department Of Internal Medicine Nihon University School Of Medicine
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IZUMI YOICHI
The 2nd Department of Internal Medicine Nihon University School of Medicine
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