CYCLIC GMP FORMATION OF RESISTANCE VESSEL IN THE DEVELOPMENT OF HYPERTENSION IN SPONTANEOUSLY HYPERTENSIVE RATS
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概要
- 論文の詳細を見る
We investigated the basal levels and responses of cyclic GMP (cGMP) derived from perfused mesenteric arteries to acetylcholine (ACh) and sodium nitroprusside (SNP) in spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY) at different ages, in order to evaluate the basal and stimulated release of endothelium-derived relaxing factor (EDRF) from the resistance vessel during the development of hypertension. The mesenteric arteries were removed from 8-, 12- and 20-week-old WKY and SHR, and were perfused with Krebs-Henseleit solution containing 0.2 mM isobutyl methyl xanthine. The effluents from the perfused arteries were corrected before and after infusions of graded doses of ACh or SNP, and the levels of cGMP were measured. The basal levels of cGMP from the msenteric arteries in the 12- and 20-week-old SHR were significantly lower than those in age-matched WKY. A negative correlation was observed between the basal levels of cGMP and the systolic blood pressure in SHR, but not in WKY, among all ages. On the other hand, there were no differences in the responses of cGMP to infusion of ACh between the WKY and SHR at each age. Moreover, the responsiveness of cGMP to in-fusion of SNP in the 12-week-old SHR was much higher than that in age-matched WKY. These data suggest that the basal cGMP formation in the arteries which may reflect the basal release of EDRF is reduced in older SHR and is associated with the development of hypertension, and that the stimulated ralease of EDRF is not associated with the development of hypertension.
- 社団法人日本循環器学会の論文
- 1991-07-20
著者
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Soma Masayoshi
Division Of Nephrology Hypertension And Endocrinology Department Of Medicine Nihon University School
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Soma Masayoshi
日本大学 医学部内科学系腎臓高血圧内分泌内科
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Soma Masayoshi
Second Department Of Internal Medicine Nihon University School Of Medicine
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Fukuda Noboru
Advanced Research Institute Of Science And Humanities Nihon University
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泉 洋一
日本大学 内科2
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Fukuda Noboru
日本大学 総合科学研究科
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Hatano Michinobu
The 2nd Dept, of Internal Medicine, Nihon Univ. School of Medicine (Dept. of Cardiology, Surugadai N
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Hatano Michinobu
The 2nd Department Of Internal Medicine Nihon University School Of Medicine
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WATANABE Yoshiyasu
Second Department of Internal Medicine, Nihon University School of Medicine
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Izumi Youichi
Department Of Cardiovascular Renal And Endocrine Medicines Research Center And Cardiovascular Functi
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IZUMI Yoichi
Div. of Cardiovascular Med. Nihon Univ. Sch. of Med
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Minato Masaya
Second Department Of Internal Medicine Nihon University School Of Medicine
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FUKUDA NOBURU
The 2nd Department of Internal Medicine, Nihon University School of Medicine
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IZUMI YOICHI
The 2nd Department of Internal Medicine, Nihon University School of Medicine
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MINATO MASAYA
The 2nd Department of Internal Medicine, Nihon University School of Medicine
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SOMA MASAYOSHI
The 2nd Department of Internal Medicine, Nihon University School of Medicine
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WATANABE YOSHIYASU
The 2nd Department of Internal Medicine, Nihon University School of Medicine
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WATANABE MASASHI
The 2nd Department of Internal Medicine, Nihon University School of Medicine
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Hatano M
The 2nd Department Of Internal Medicine Nihon University School Of Medicine
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Hatano Michinobu
The 2nd Department Of Internal Medicine And Radiology Nihon University
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Soma Masayoshi
Division Of Nephrology And Endocrinology Department Of Medicine Nihon University School Of Medicine
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Honda M
The 2nd Department Of Internal Medicine Nihon University School Of Medicine
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Watanabe Yoshiyasu
Second Department Of Internal Medicine Nihon University School Of Medicine
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Sato Mikano
Division Of General Medicine Department Of Internal Medicine Nihon University School Of Medicine
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Watanabe Masashi
The 2nd Department Of Internal Medicine Nihon University School Of Medicine
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Hatano M
The Second Department Of Internal Medicine Nihon University School Of Medicine
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IZUMI YOICHI
The 2nd Department of Internal Medicine Nihon University School of Medicine
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