Rationale, Design, and Organization of the Diastolic Heart Failure Assessment Study in Tohoku District(DIAST)
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概要
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Background High mortality and a high readmission rate characterize diastolic heart failure (DHF), but evidence-based therapeutic strategies have not been established for DHF. Methods The aim of a multicenter, randomized open trial (the Diastolic Heart Failure Assessment Study in Tohoku District, DIAST) is to evaluate the safety and prognostic efficacy of the multiple action non-selective β-blocker carvedilol in 160 patients with DHF (left-ventricular ejection fraction ≥50%). The target dose of carvedilol is 10mg twice a day and the mean follow-up is estimated to be 2 years. The primary endpoints are to evaluate (1) all-cause mortality or hospitalization, (2) cardiovascular mortality or hospitalization and (3) worsening heart failure. The secondary endpoints are to assess (1) cardiovascular events, (2) the individual components of the above combined endpoints, (3) the duration of hospitalization, (4) the functional class and exercise capacity and (5) the safety and tolerability. All patients' data are processed using an original registration system on an internet homepage. Several substudies to assess neurohumoral factors, heart rate variability, oxidative stress and sleep apnea will clarify the pathophysiology of DHF. Conclusions The DIAST will contribute to establish therapeutic guidelines for DHF.
- 社団法人日本循環器学会の論文
- 2004-06-20
著者
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Hoshi Nobuo
Miyako Prefectural Hospital
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Shirato Kunio
Tohoku University
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Takahashi Chiaki
東北大学 医学部量子診断学
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Soma Masayoshi
Division Of Nephrology Hypertension And Endocrinology Department Of Medicine Nihon University School
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Soma Masayoshi
日本大学 医学部内科学系腎臓高血圧内分泌内科
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HAYASHI Masato
Hiraka General Hospital
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Soma Masayoshi
Division Of General Medicine Department Of Medicine Nihon University School Of Medicine
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Takahashi Shoki
Department Of Radiology Tohoku University Graduate School Of Medicine
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Ikeda Jun
Sendai Red Cross Hospital
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Kikuchi Junichi
Towada City Hospital
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Shinozaki Tsuyoshi
Tohoku University Graduate School of Medicine
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Watanabe Jun
Tohoku University Graduate School of Medicine
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Tamaki Kenji
Iwate Prefectural Central Hospital
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Onodera Yukio
Ogachi Central Hospital
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Hiramoto Tetsuya
National Sendai Hospital
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Sakuma Masahito
Tohoku University Graduate School of Medicine
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Fukuchi Mitsumasa
Tohoku Kosai Hospital
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Sugi Masafumi
Iwaki Kyoritu Hospital
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Kagaya Yutaka
Tohoku University Graduate School of Medicine
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Sakuma Masahiko
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Fukuchi Mitsumasa
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Takase Kei
Department Of Diagnostic Radiology Tohoku University Graduate School Of Medicine
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Suzuki Takashi
Department Of Radiology Tohoku University Graduate School Of Medicine
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Kikuchi Junichi
Towada City Central Hospital
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Takase Kei
Iwate Prefectural Central Hospital
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Ikeda Jun
The Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Sugi Masafumi
女川町立病院 内科
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Sonoda Masahiro
Second Department Of Cardiology National Hospital Organization Kagoshima Medical Center
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