ADENYLATE CYCLASE ACTIVITIES OF VASCULAR SMOOTH MUSCLE IN EARLY AND ESTABLISHED DOCA/SALT HYPERTENSIVE RATS : 51st Annual Meeting of the Japanese Circulation Society

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概要

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• It has been demonstrated that the adenylate cyclase activity of vascular smooth muscle regulates its tonus. The present study was undertaken to examine adenylate cyclase activity in early and established deoxycorticosterone acetate (DOCA)/salt hypertensive rats. Early and established DOCA/salt hypertensive rats were prepared by injecting 30 mg of DOCA weekly for 3 and 10 weeks, respectively, into male Wistar rats given drinking water with l% saline. The membrane protein fraction of the aorta was obtained by centrifugation at 37,000 g. To the incubation medium containing the protein, 50μM isoproterenol, 100μM GTP, 50μM forskolin or 25μM calmodulin was applied. The adenylate cyclase activity was determined by a modified method developed in our laboratory using double. isotope counting. The adenylate cyclase activity in the early DOCA/salt hypertensive rats was significantly higher (p < 0.05) than that in the control rats in the basal condition, which was unaffected by additions of isoproterenol, GTP or forskolin. There was no significant difference in basal adenylate cyclase activity between the established DOCA/salt hypertensive and control rats. The adenylate cyclase activities in the established DOCA/salt hypertensive rats were significantly lower with GTP (p < 0.02) and forskolin (p < 0.01) as compared with the control rats. Calmodulin elevated the adenylate cyclase activity significantly (p < 0.05) in the established DOCA/salt hypertensive rats as well as in the control rats. However, enzyme activity with calmodulin in the established DOCA/salt hypertensive rats was significantly lower (p < 0.05) than that in the control rats. These results suggest that the adenylate cyclase activity of vascular smooth muscle in early DOCA/salt hypertension was fully stimulated in the basal condition, and that there was an abnormality distal to the β-adrenoceptor, especially the catalytic subunit of the adenylate cyclase in established DOCA/ salt hypertension. Accordingly, it is thought that reduction of the enzyme activity may be attributable in part, to biochemical events involved in the pathogenesis of DOCA/salt hypertension.

• 社団法人日本循環器学会の論文
• 1990-01-20

著者

• Soma Masayoshi

  Division Of Nephrology Hypertension And Endocrinology Department Of Medicine Nihon University School

• Soma Masayoshi

  日本大学 医学部内科学系腎臓高血圧内分泌内科

• Soma Masayoshi

  Second Department Of Internal Medicine Nihon University School Of Medicine

• Fukuda Noboru

  Advanced Research Institute Of Science And Humanities Nihon University

• 泉 洋一

  日本大学 内科2

• Fukuda Noboru

  日本大学 総合科学研究科

• Hatano Michinobu

  The 2nd Dept, of Internal Medicine, Nihon Univ. School of Medicine (Dept. of Cardiology, Surugadai N

• Hatano Michinobu

  The 2nd Department Of Internal Medicine Nihon University School Of Medicine

• Izumi Youichi

  Department Of Cardiovascular Renal And Endocrine Medicines Research Center And Cardiovascular Functi

• IZUMI Yoichi

  Div. of Cardiovascular Med. Nihon Univ. Sch. of Med

• Fukuda Noboru

  The 2nd Department Of Internal Medicine Nihon University School Of Medicine

• Minato Masaya

  Second Department Of Internal Medicine Nihon University School Of Medicine

• IZUMI YOICHI

  The 2nd Department of Internal Medicine, Nihon University School of Medicine

• MINATO MASAYA

  The 2nd Department of Internal Medicine, Nihon University School of Medicine

• SOMA MASAYOSHI

  The 2nd Department of Internal Medicine, Nihon University School of Medicine

• HONDA MASANOBU

  The 2nd Department of Internal Medicine, Nihon University School of Medicine

• Hatano M

  The 2nd Department Of Internal Medicine Nihon University School Of Medicine

• Hatano Michinobu

  The 2nd Department Of Internal Medicine And Radiology Nihon University

• Honda Masanobu

  The 2nd Department Of Internal Medicine Nihon University School Of Medicine

• Soma Masayoshi

  Division Of Nephrology And Endocrinology Department Of Medicine Nihon University School Of Medicine

• Sato Mikano

  Division Of General Medicine Department Of Internal Medicine Nihon University School Of Medicine

• IZUMI YOICHI

  The 2nd Department of Internal Medicine Nihon University School of Medicine

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