IODINE 125-PHENYLPENTADECANOIC ACID AND ITS BETA-METHYL SUBSTITUTE METABOLISM IN CULTURED MOUSE EMBRYONAL MYOCYTES : Iodine-labelled Fatty Acids as Tracers of Myocardial High Energy Phosphate
スポンサーリンク
概要
- 論文の詳細を見る
Iodine-labelled fatty acids have been proposed as new tracers of cardiac metabolisms. However, it is not clear how these tracers would reflect the intracellular metabolism. Therefore, we measured the uptake and release of iodine 125-labelled phenylpentadecanoic acid (IPPA), its β-methyl substitute (BMIPP) and ^<201>Tl in cultured myocytes of mouse embryos, and compared these values to intracellular adenosine triphosphate (ATP) content after metabolic inhibitions of oxidative phosphorylation by sodium cyanide (CN), glycolysis by 2-deoxyglucose (2-DG) or fatty acid β-oxidation by lactate. The uptake and release of BMIPP was not changed by any inhibitors suggesting BMIPP would not be metabolized in the myocytes. The uptake of IPPA was significantly reduced by 2DG and 60-80% of IPPA was metabolized to hydrophilic catabolites. The correlation of BMIPP and IPPA uptake to intracellular ATP content were high (r=0.89, p<0.05; r=0.86, p<0.1), but there was poor correlation of ^<201>Tl to ATP values (r=0.53, n.s.). These results suggested that iodine-labelled fatty acids could be used as better tracers of myocardial metabolism than ^<201>Tl.
- 社団法人日本循環器学会の論文
- 1993-05-20
著者
-
Nakamura Haruo
1st Department of Internal Medicine, National Defense Medical College
-
Ohsuzu Fumitaka
1st Department of Internal Medicine, National Defense Medical College
-
Ishida Hideyuki
Department of Medicine, National Defense Medical College
-
Aosaki Noboru
National Kasumigaura Hospital
-
Sakata Nobuhiro
1st Department Of Medicine National Defense Medical College
-
Nakamura Haruo
Department Of Medicine I National Defense Medical College
-
Ohsuzu Fumitaka
Department Of Medicine I National Defense Medical College
-
Ohsuzu Fumitaka
First Division Department Of Internal Medicine National Defence Medical College
-
OKANO MITSUJI
1st Department of Medicine, National Defense Medical College
-
KATSUSHIKA SHUUICHI
1st Department of Medicine, National Defense Medical College
-
Aosaki Noboru
Department Of Medicine National Defense Medical College
-
Ishida Hideyuki
Department Of Physiology 2 School Of Medicine Tokai University
-
Okano Mitsuji
1st Department Of Medicine National Defense Medical College
-
Katsushika Syuichi
Department Of Radiology National Defense Medical College
-
Nakamura Haruo
1st Department Of Medicine National Defense Medical College
-
Ohsuzu Fumitaka
1st Department Of Medicine National Defense Medical College
-
Ohsuzu Fumitaka
Internal Medicine National Defense Medical College
-
Nakamura Haruo
1st Department Of Internal Medicine National Defense Medical College
-
Ishida Hideyuki
Department Of Digestive Tract And General Surgery Saitama Medical Center Saitama Medical University
-
Katsushika Shuichi
1st Department Of Medicine National Defense Medical College
-
Ishida Hideyuki
Department of Chemistry, Faculty of Engineering Science, Osaka University
関連論文
- Fetal and Neonatal Development of Ca2+ Transients and Functional Sarcoplasmic Reticulum in Beating Mouse Hearts
- Incarcerated Recurrent Rectal Prolapse with Ileal Strangulation : Report of a Case
- PE-501 Anti-Sympathetic Action can Enhance Statin Pleiotrophic Effects : Combined Effect of Rosuvastatin and Atenolol on Endothelial Function(PE084,Lipid Disorders 2 (H),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulati
- -P79-EVALUATON OF MYOCARDIAL DAMAGE AFTER 60 MINUTES CORONARY OCCLUSION USING MYOCARDIAL CONTRAST ECHOCARDIOGRAPHY : Echocardiography, Pulsed Doppler : FREE COMMUNICATIONS(III) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATIO
- CHANGES OF PLATELET FUNCTION AND PROSTAGLANDIN METABOLISM DURING TREADMILL TESTING AND IT'S CORRELATIONS WITH TREADMILL EXERCISE SCORE MEASURED BY DSA METHOD : Exercise Test (II) : FREE COMMUNICATIONS (VI) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETI
- -P79-EVALUATON OF MYOCARDIAL DAMAGE AFTER 60 MINUTES CORONARY OCCLUSION USING MYOCARDIAL CONTRAST ECHOCARDIOGRAPHY : Echocardiography, Pulsed Doppler : FREE COMMUNICATIONS(III) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATIO
- CHANGES OF PLATELET FUNCTION AND PROSTAGLANDIN METABOLISM DURING TREADMILL TESTING AND IT'S CORRELATIONS WITH TREADMILL EXERCISE SCORE MEASURED BY DSA METHOD : Exercise Test (II) : FREE COMMUNICATIONS (VI) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETI
- OJ-399 Enhancement of Ultrasonic Thrombus Imaging Using Perfluorocarbon Microbubbles Targeted to Activated Platelet Glycoprotein IIb/IIIa Complex in a Rabbit IIio-femoral Artery.(Echo/Doppler 14 (I) : OJ48)(Oral Presentation (Japanese))
- EFFECTS OF HYPOXIA ON BEATING RATE AND CELL INJURIES IN CULTURED MYOCARDIAL CELL : WITH SPECIAL REFERENCE TO ATP CONTENT : Cardiac Metabolism (I) : 48 Annual Scientific Meeting, Japanese Circulation Society
- BETA-ADRENERGIC RECEPTORS IN THE MYOCARDIUM OF SPONTANEOUSLY HYPERTENSIVE RATS : Hypertension (III) : III : 48 Annual Scientific Meeting, Japanese Circulation Society
- EVALUATION OF CONTRACTION VELOCITY IN SINGLE CULTURED MYOCARDIAL CELLS : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Myocardial Metabolism Biochemistry
- EFFECTS OF PROSTANOIDS ON CULTURED MYOCARDIAL CELLS : Myocardial metabolism . Biochemistry : 46th Annual Scientific Meeting, Japanese Circulation Society
- PE-011 The maintenance of intracellular Ca2+ overload in the auto-immunized hypertrophied cardiomyopathy rabbit model(Arrhythmia, Basic 3 (A) : PE2)(Poster Session (English))
- Effect of Chronic Autoimmunity against the Second Extracellular Loop of Beta1-Adrenergic Receptors to Inward Currents in Ventricular Myocytes
- Soluble Elastin Decreases in the Progress of Atheroma Formation in Human Aorta
- PJ-390 HOP-9P Enhanced Magnetic Resonance Imaging of Atherosclerotic Plaques in Rabbit Aorta(MRI/MRA-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-306 Effects of Lipid-Lowering Therapy with Atorvastatin on Thoracic and Abdominal Aortic Plaques : Two Years' Follow-up by MRI(Atherosclerosis, clinical-09, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-341 Comparative Beneficial Effect of Combination of Calcium-Blocker and Beta-Blocker with and without Vasodilating Action on Heart Rate Variability in Hypertension(OE58,Hypertension, Clinical 2 (H),Oral Presentation (English),The 73rd Annual Scientific
- PE-314 Significant Role of Cardiac Autonomic Nerve Activity Assessed by Heart Rate Variability Measured during Exercise in Suspected Coronary Artery Disease(ECG/Body surface potential mapping/Holter(04)(A),Poster Session(English),The 72nd Annual Scientifi
- PE-090 Novel Equipment for Measuring Flow-Mediated Vasodilation in Brachial Artery ; Detection of Subacute Effect of Statin and Changes in Cytokines(Endothelium(02)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulatio
- A Case of Acute Massive Pulmonary Thromboembolism Treated by Mechanical Clot Fragmentation Using a Percutaneous Transluminal Angioplasty Balloon
- Primitive Neuroectodermal Tumor Arising in the Colon : Report of a Case
- Plasma Levels of Big Endothelin-1 in Patients with Colorectal Cancer : Correlation with Liver Metastasis
- Impact of Oral Antimicrobial Prophylaxis on Surgical Site Infection and Methicillin-Resistant Staphylococcus aureus Infection After Elective Colorectal Surgery, Results of a Prospective Randomized Trial
- OJ-229 Pre-procedural Plasma Osteopontin (OPN) Levels and Cardiovascular Events in Patients Undergoing Percutaneous Coronary Intervention (PCI)(Restenosis, basic/clinical-2 (IHD) OJ39,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Mee
- HETEROGENEOUS RESPONSE OF REGIONAL WALL MOTION OF NORMAL LEFT VENTRICLE WITH RIGHT ATRIAL PACING USING TWO DIMENSIONAL ECHOCARDIOGRAPHY : Echocardiography (I) : FREE COMMUNICATIONS (III) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE
- Carcinosarcoma of the Rectosigmoid Colon : Report of a Case
- Pseudo-Meigs' Syndrome Caused by Ovarian Metastasis from Colon Cancer : Report of a Case
- 0591 DEVELOPMENTAL CHANGES OF SYMPATHETIC INNERVATION AND β-ADRENERGIC RECEPTOR DENSITY IN THE RAT MYOCARDIUM
- Sweet Elements of Siraitia Grosvenori Inhibit Oxidative Modification of Low-Density Lipoprotein
- 11) INCIDENCES OF CORONARY ARTERY STENOSIS AND MEAN QRS VECTOR ON THE FRONTAL PLANE VECTORCARDIOGRAM IN PATIENTS WITH INFERIOR MYOCARDIAL INFARCTION
- OJ-080 Associations between Plasma C-reactive Protein (CRP) and Osteopontin (OPN) Levels and the Severities of Aortic and Coronary Atherosclerosis(OJ14,Atherosclerosis (Clinical/Diagnosis) (IHD),Oral Presentation (Japanese),The 73rd Annual Scientific Meet
- Prognostic Significance of Plasma Osteopontin Levels in Patients Undergoing Percutaneous Coronary Intervention(Ischemic Heart Disease)
- FRS-104 Associations between Plasma Osteopontin (OPN) Levels and the Severity of Aortic and Coronary Atherosclerosis(Clinical Frontiers in Atherosclerosis(IHD),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Societ
- Telmisartan Enhances Cholesterol Efflux from THP-1 Macrophages by Activating PPARγ
- Plasma Matrix Metalloproteinase-8 Concentrations are Associated With the Presence and Severity of Coronary Artery Disease
- Polymorphism of the 3'-Untranslated Region of Interleukin-12 p40 Gene is not Associated With the Presence or Severity of Coronary Artery Disease
- High Plasma Levels of Osteopontin (OPN) in Patients With Restenosis after Percutaneous Coronary Intervention (PCI)(Restenosis after Angioplasty, Basic/Clinical 5 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-478 Plasma Matrix Metalloprotease (MMP)-8 Levels Are Associated With the Presence and Severity of Coronary Artery Disease (CAD)(Angina Pectoris, Clinical 3 (IHD) : OJ58)(Oral Presentation (Japanese))
- Effects of Lipid-Lowering by Atorvastatin on Atherosclerotic Plaques in Thoracic and Abdominal Aorta Detected by MRI
- Protective Effect of Green Tea Consumption Against Myocardial Infarction (MI)
- Can MRI be an Ideal, Noninvasive Tool For Plaque Characterization?
- Effects of interleukin (IL) gene polymorphisms on the development of coronary artery disease (CAD) associated with chlamydia pneumoniae (CP) infection
- Imaging Techniques for Measuring Adipose-tissue Distribution in the Abdomen: A Comparison between Computed Tomography and 1.5-Tesla Magnetric Resonance Spin-echo Imaging
- Relation of Abdominal and Thigh Adipose Tissue Distribution to Serum Lipids and Glucose Metabolism in Obese Males
- R192Q Paraoxonase Gene Variant is Associated with a Change in HDL-Cholesterol Level during Dietary Caloric Restriction in Nondiabetic Healthy Males
- Effect of Alcohol Intake on the Levels of Plasma Homocysteine in Healthy Males
- IODINE 125-PHENYLPENTADECANOIC ACID AND ITS BETA-METHYL SUBSTITUTE METABOLISM IN CULTURED MOUSE EMBRYONAL MYOCYTES : Iodine-labelled Fatty Acids as Tracers of Myocardial High Energy Phosphate
- -145-SIMULTANEOUS MEASUREMENT OF ACTION POTENTIAL AND CONTRACTION VELOCITY IN CULTURED CARDIAC CELLS
- -0865-THE EFFICACY OF ARGON LASER-MEDIATED HOT BALLOON ANGIOPLASTY : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -0755-THE UTILITY OF PERCUTANEOUS TRANSLUMENAL CORONARY ANGIOSCOPE WITH OVER THE GUIDE WIRE SYSTEM (OGS)
- -0703-RISK OF THROMBOEMBOLISM BY GUIDWIRES FOR PTCA
- -0186-COMPARISON OF FINDINGS BETWEEN CORONARY ANGIOGRAPHY AND ANGIOSCOPY
- Important Regulatory Role of Activated Platelet-Derived Procoagulant Activity in the Propagation of Thrombi Formed Under Arterial Blood Flow Conditions(Vascular Medicine)
- OJ-047 Role of ADP Receptors P2Y_1 and P2Y_ in the Maintenance of Stability of Platelet Thrombi under Blood Flow Conditions.(Antithrombofic Ttherapy (H) : OJ6)(Oral Presentation (Japanese))
- Imaging of Structural Changes in Endothelial Cells and Thrombus Formation at the Site of FeCl_3-Induced Injuries in Mice Cremasteric Arteries
- -457-PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOSCOPY : USEFULNESS AND COMPLICATIONS : Ischemic Heart Disease I : FREE COMMUNICATIONS(II) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -P78-STUDY OF MYOCARDIAL CONTRAST WASHOUT "T1/2" USING LOW OSMORALITY CONTRAST AGENT IOPAMIDOL : Echocardiography, Pulsed Doppler : FREE COMMUNICATIONS(III) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Multiple Inflammatory Pseudotumors Mimicking Liver Metastasis from Colon Cancer : Report of a Case
- A Case of Breast Cancer Diagnosed by Inguinal Lymph Node Metastasis
- ENHANCED MYOCARDIAL ADENYLATE CYCLASE ACTIVITY IN SPONTANEOUSLY HYPERTENSIVE RATS
- Effects of Fura-2 and Indo-1 on [Ca^]i in Spontaneously Beating Cultured Heart Cells
- -1271-AN EFFECT OF EXTERNAL K ON Ca-H INTERACTION IN CULTURED HEART CELLS : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -0890-EFFECTS OF HUMAN SUPEROXIDE DISMUTASE ON ISCHEMIC AND REPERFUSED MYOCARDIUM IN ISOLATED PERFUSED RAT HEART : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -0568-SEVERE MYOCYTE ATP DEPLETION OR Ca OVERLOAD PREDUCE IRREREVERSIBLE CELL INJURY IN CULTURED HEART CELLS
- -0360-EFFECTS OF PDGF AND INSULIN ON LOW DENSITY LIPOPROTEIN METABOLISM AND PROLIFERATION IN CULTURED MEDIAL SMOOTH MUSCLE CELLS
- INTERRELATIONSHIP BETWEEN IODINE 125PENTADECANOIC ACID AND ITS BETA-METHYL SUBSTITUTE METABOLISM AND MYOCARDIAL HIGH ENERGY PHOSPHATE : RI : 53 Annual Scientific Meeting, Japanese Circulation Society
- EFFECTS OF DILTIAZEM ON ACETYLATED LOW DENSITY LIPOPROTEIN METABOLISM IN CULTURED MOUSE PERITONEAL MACROPHAGES : Arteriosclerosis : 53 Annual Scientific Meeting, Japanese Circulation Society
- -P169- EFFECTS OF CALCIUM ANTAGONIST AND FREE RADICAL SCAVENGERS ON ISCHEMIC AND REPERFUSED MYOCARDIUM
- Effects of Soy Protein on Levels of Remnant-like Particles Cholesterol and Vitamin E in Healthy Men
- Changes in the Concentration and Distribution of Lipoprotein(a) in Plasma after Fat Intake
- REMNANT LIKE PARTICLES(RLP),WHICH WAS ISOLATED BY USING IMMUNOAFFINITY GEL MIXTURE TO APO B100 AND APO A-1 FROM HYPERTRIGLYCERIDEMIC PATIENTS, SUPPRESSED HMG COA REDUCTASE ACTIVITY OF HUMAN SKIN FIBROBLASTS
- Anorectal Agenesis with a Rectourethral Fistula Diagnosed in an Adult : Report of a Case
- Use of Head-Up Tilt Testing to Determine a Possible Cause of Unexpected Cardiac Asystole During Epidural Anesthesia
- The Quantitative Appraisal of Coronary Vascular Lesions in Experimental Hypertension and Hypercholesterolemia with Special Reference to Intramural Arteriolosclerosis
- OE-025 Cardioprotection by Erythropoietin is Associated with Translocation of Akt to Mitochondria and Its Interaction with the Adenine Nucleotide Translocase(Myocardial ischemia-reperfusion, basic/clinical-1 (IHD) OE5,Oral Presentation (English),The 70th
- Effects of Calcium Antagonists and Free Radical Scavengers on Myocardial Ischemic and Reperfusion Injury: Evaluation by ^P-NMR Spectroscopy : SYMPOSIUM ON PROTECTION OF ISCHEMIC MYOCARDIUM : Basic and Clinical Research
- Haloperidol Prolongs Diastolic Phase of Ca^ Transient in Cardiac Myocytes
- Difference in Propagation of Ca^ Release in Atrial and Ventricular Myocytes
- Physiological Concentration of Nitric Oxide Induces Positive Inotropic Effects through cGMP Pathway in Isolated Rat Ventricular Myocytes
- Bromodeoxyuridine Uptake by Early Liver Metastases in Rats : A Comparison of the Hepatic Artery and Portal Vein Infusion Routes
- Splenic and Pulmonary Metastases from Renal Cell Carcinoma : Report of a Case
- A Foreign Body Granuloma After Gastric Perforation Mimicking Peritoneal Dissemination of Gastric Cancer : Report of a Case
- Amebic liver abscess rupturing into the lesser omentum space
- MARKED DIFFERENCE IN ROLES OF SUPEROXIDE, NO AND PEROXYNITRITE BETWEEN MYOCYTE AND ENDOTHELIAL CELL INJURY
- Effect of calcium and magnesium on neurotoxicity and blood platinum concentrations in patients receiving mFOLFOX6 therapy : a prospective randomized study
- Stanniocalcin 1 Prevents Cytosolic Ca^ Overload and Cell Hypercontracture in Cardiomyocytes
- Stanniocalcin 1 Attenuates the Cytosolic Ca Overload And the Cell Hypercontracture Induced by Ouabain (Heart Failure, Basic 6 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Nicorandil Attenuates FeCl_3-Induced Thrombus Formation Through the Inhibition of Reactive Oxygen Species Production(Vascular Medicine)
- Short-Term Intravenous Antimicrobial Prophylaxis in Combination with Preoperative Oral Antibiotics on Surgical Site Infection and Methicillin-Resistant Staphylococcus aureus Infection in Elective Colon Cancer Surgery : Results of a Prospective Randomized
- Gastrointestinal Stromal Tumor Arising in the Pelvic Cavity : A Case Report
- Muscle Strength and Walking Ability After Laparoscopic Hernioplasty Versus Conventional Repair
- THE EFFECTS OF CoQ_, DEX AND MP DURING HYPOXIA : A STUDY ON THE CULTURED SINGLE MYOCARDIAL CELL : Cardiovascular drugs (I) : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- APC gene mutations in a jejunal adenoma causing intussusception in a patient with familial adenomatous polyposis
- Serum Levels of Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) in Colorectal Cancer Patients
- Fulminant amoebic colitis with perforation successfully treated by staged surgery : a case report
- Pseudo-Meigs'syndrome caused by ovarian metastasis from rectosigmoid cancer
- Risk of Missing Colorectal Cancer During Laparoscopic Cholecystectomy
- The Facilitation of Peritoneal Dissemination of a Tumor by Laparotomy in a Rabbit Model
- A New Simple Technique for Performing Intraoperative Endoscopic Resection of Small-Bowel Polyps in Patients with Peutz-Jeghers Syndrome