A STUDY ON DEHYDROEPIANDROSTERONE SULFATE IN PATIENTS WITH ESSENTIAL HYPERTENSION
スポンサーリンク
概要
- 論文の詳細を見る
Alterations in the concentration of plasma dehydroepiandrosterone sulfate (DHEA-S) and cortisol in patients with essential hypertension (EH) were investigated. The subjects were 25 patients with EH: 7 of low plasma renin activity (PRA) group, 10 of normal PRA group and 8 of high PRA group; 7 normal subjects were used as the controls. Plasma DHEA-S and cortisol were measured before and after the following tests: (1) circadian rhythm (6:00, 16:00 and 24:00), (2) furosemide (0.7 mg/kg) test, (3) ACTH (12.5 IU/4 hr) infusion test, (4) dexamethasone (1.0 mg) test, (5) furosemide (0.7 mg/kg) test under dexamethasone (1.0 mg) treatment, (6) metopirone (1.5 g) test, (7) angiotensin II (8 ng/kg/min, 30 min) infusion test and (8) saline (1000 ml/hr) test. The alterations of the endogenous ACTH-adrenal hormone system as well as the renin-angiotensin-aldosterone system induced by these tests did not cause significant changes in plasma levels of DHEA-S in the 3 groups with EH. However, significant enhancement of plasma DHEA-S was observed after both the administration of exogenous ACTH and angiotensin II. It is considered that the responsiveness of DHEA-S to ACTH may increase in the low and normal PRA groups and that the responsiveness of DHEA-S to angiotensin II may increase in the high PRA group. Based on these results, it is suggested that plasma DHEA-S hardly or only partially participates as a causal factor of EH.
- 社団法人日本循環器学会の論文
- 1982-06-20
著者
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Hatano Michinobu
The Second Department Of Internal Medicine Nihon University School Of Medicine
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Hatano Michinobu
The 2nd Department Of Internal Medicine Nihon University School Of Medicine
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HONDA MASANOBU
The 2nd Department of Internal Medicine, Nihon University School of Medicine
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Hatano M
The 2nd Department Of Internal Medicine Nihon University School Of Medicine
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HONDA MASANOBU
The Second Department of Internal Medicine, Nihon University School of Medicine
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TSUCHIYA MAKOTO
The Second Department of Internal Medicine, Nihon University School of Medicine
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Honda Masanobu
The 2nd Department Of Internal Medicine Nihon University School Of Medicine
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Honda Masanobu
The Second Department Of Internal Medicine Nihon University School Of Medicine Tokyo Japan
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Hatano M
The Second Department Of Internal Medicine Nihon University School Of Medicine
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