RELATIONSHIP BETWEEN BLOOD PRESSURE AND BLOOD LEVELS OF ANGIOTENSIN I CONVERTING ENZYME INHIBITOR (SQ14,225)
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概要
- 論文の詳細を見る
The time courses of mean blood pressure (MBP), plasma renin activity (PRA), plasma aldosterone (PA), serum prostaglandin E (PGE), serum angiotensin I converting enzyme (ACE), and blood levels of angiotensin I converting enzyme inhibitor (SQ 14,225) (captopril) were studied in 6 patients with essential hypertension (5 men and I woman, aged 44 ± 5.6 (mean ± S.E.) years) before and 30, 60, 120 and 180 min after administration of 25 mg captopril, MBP and ACE began to fall within 30 min and reached a significant mini-mum between 60 and 180 min after captopril administration. PRA was significantly increased 60 min after captopril administration and continued for 180 min. On the other hand, PA had begun to fall significantly 180 min after captopril administration. The blood levels of captopril were significantly increased 30 min after captopril administration, with a peak at 120 min. The levels at 180 min were half the peak. The levels of PGE were not significantly changed within 180 min after captopril administration. These results suggest a discrepancy between the changes in MBP and the blood levels of captopril. The blood pressure lowering effect may be due to inhibition of angiotensin II (Ang. II) during the short-acting effect, and due to decrease of PA, metabolites of captopril, increase of kinin in the blood, inhibition of the slow pressor effect of Ang. II, increases of other depressor hormones such as prostacyclin and other depressor mechanisms during the long-acting effect.
- 社団法人日本循環器学会の論文
- 1981-09-20
著者
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泉 洋一
日本大学 内科学講座腎臓内分泌内科部門
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泉 洋一
日本大学 内科2
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泉 洋一
日本大学 医学部病態病理学系臨床検査医学分野
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Hatano Michinobu
The Second Department Of Internal Medicine Nihon University School Of Medicine
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Hatano Michinobu
The 2nd Department Of Internal Medicine Nihon University School Of Medicine
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泉 洋一
日本大学医学部内科学系腎臓高血圧内分泌内科分野
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Izumi Yoichi
The Second Department of Internal Mesicine, Nihon University School of Medicine
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IZUMI Yoichi
Div. of Cardiovascular Med. Nihon Univ. Sch. of Med
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HONDA MASANOBU
The 2nd Department of Internal Medicine, Nihon University School of Medicine
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Hatano M
The 2nd Department Of Internal Medicine Nihon University School Of Medicine
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HONDA MASANOBU
The Second Department of Internal Medicine, Nihon University School of Medicine
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KAWAHARA YUKINORI
Product Development Laboratories, Sankyo Company, Ltd
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Kawahara Yukinori
Product Development Laboratories Sankyo Company Ltd
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Honda Masanobu
The 2nd Department Of Internal Medicine Nihon University School Of Medicine
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Honda Masanobu
The Second Department Of Internal Medicine Nihon University School Of Medicine Tokyo Japan
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Izumi Yoichi
The Second Department Of Internal Medicine Nihon University School Of Medicine
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Hatano M
The Second Department Of Internal Medicine Nihon University School Of Medicine
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