ABNORMAL RESPONSE OF ADRENOCORTICOTROPIN TO CORTICOTROPIN RELEASING FACTOR IN SPONTANEOUSLY HYPERTENSIVE RATS

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The pituitary-adrenocortical response to ovine corticotropin-releasing factor (CRF) was investigated in spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY) anesthetized with pentobarbital. After intravenous administration of various doses of CRF (0.1, 1.0 and 10μg), the plasma levels of ACTH were significantly increased in both groups. ACTH increments after various does of CRF were dose-dependent in WKY. ACTH increments after injections of 0.1, 1.0 and 10μg of CRF in SHR were 123.2±36.5 (SE), 123.0±52.2 and 60.3±48.5 pg/ml at 5 min, and 386.3±73.8, 243.4±86.6 and 220.0±31.4 pg/ml at 15 min, respectively. The ACTH increments in SHR at 15 min after administration of 0.1 μg of CRF were higher (p<0.02) than those in WKY. However, ACTH increments in SHR after administration of 10 μg of CRF were lower than those in WKY at 5 min (p<0.05) and 15 min. These data suggest that the plasma ACTH responses to various does of CRF represent a dose-unrelated plateau response in SHR. The plasma levels of corticosterone after administration of various does of CRF did not change significantly and there were no significant differences between the two strains. The results of these experiments suggest that SHR have an abnormal reponse of the pituitary-adrenocortical axis to CRF, and the abnormal response may be attributable to desensitization of the pituitary to CRF.
社団法人日本循環器学会の論文
1987-05-20