Ambulatory Long-term Vasodilator Therapy for Chronic Refractory Heart Failure : Hemodynamic Evaluation and Clinical Response : SYMPOSIUM ON HEART FAILURE AND VASODILATOR THERAPY
スポンサーリンク
概要
- 論文の詳細を見る
We evaluated long-term combine vasodilator therapy (hydralazine or ecarazine + isosorbide dinitrate) in 29 patients with chronic congestive heart failure resistant tot the optimal conventional therapy. There were 24 men and 5 women, aged 28 to 76 years (mean 52 y/o). The etiology of heart failure was congestive cardiomyopathy in 24 patients, ischemic cardiomyopathy in 4 patients and advanced mitral regurgitation due to calcified mitral annulus in 1 patient. There were 21 patients in NYHA class III and 8 patients in NYHA class IV. All patients continued their previous therapeutic regimen during the period of this study. Hemodynamic measurements were performed with a triple lumen flow-directed baloon-tipped catheter in 20 patients to evaluate the effects of vasodilator therapy. In the rest of 9 patients, heart rate, blood pressure, chest X-ray examination for heart size (CTR) and M-mode echo-cardiograms for ejection fraction (EF) were monitored. The hemodynamic responses to the combined vasodilator therapy in 20 patients showed significant decreases in afterload and preload concomitant with an increase in cardiac output. The noninvasive evaluation of combined vasodilator therapy in 9 patients resulted in significant improvement in CTR and EF. We also noted a significant improvement in their symptoms of 29 patients. Side effects and drug toxicity were uncommon during vasodilator therapy. It is concluded that the combined vasodilator therapy is most useful adjunctive therapy in the management of severe refractory heart failure. Moreover, long-term nonparenteral vasodilators can be administered even at outpatient clinic without hemodynamic monitoring.
- 社団法人日本循環器学会の論文
- 1984-04-20
著者
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Hatano Michinobu
The 2nd Dept, of Internal Medicine, Nihon Univ. School of Medicine (Dept. of Cardiology, Surugadai N
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Hatano Michinobu
The Second Department Of Internal Medicine School Of Medicine Nihon University
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Ozawa Yukio
The 2nd Department of Internal Medicine, Nihon University School of Medicine University of North Car
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Nagasawa Masaki
Second Department of Internal Medicine, Nihon University School of Medicine
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Hatano Michinobu
The 2nd Department Of Internal Medicine And Radiology Nihon University
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Nagasawa Masaki
The 2nd Department of Internal Medicine, Nihon University School of Medicine
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Saito Satoshi
The 2nd Department of Internal Medicine, Nihon University School of Medicine
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Tamura Yasuo
The 2nd Department of Internal Medicine, Nihon University School of Medicine
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YUMIKURA Sei
The 2nd Dept. of Med., Nihon Univ. School of Medicine
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HIBIYA Kazuhira
The 2nd Dept. of Med., Nihon Univ. School of Medicine
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Tomobe Kentaro
The 2nd Department of Internal Medicine Nihon University School of Medicine
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ICHIKAWA MASAYUKI
The 2nd Department of Internal Medicine, Nihon University School of Medicine
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Yumi-kura Sei
The 2nd Department Of Internal Medicine Nihon University School Of Medicine
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Nagasawa Masaki
Second Department Of Internal Medicine Nihon University School Of Medicine
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Hibiya Kazuhira
Second Department Of Internal Medicine Nihon University School Of Medicine
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Ichikawa Masayuki
The 2nd Department Of Internal Medicine Nihon University School Of Medicine
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Takagi Yasuhiro
The Second Department Of Medicine Nihon University Shool Of Medicine
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Takagi Yasuhiro
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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