Disopyramide : A Promising New Approach to the Medical Treatment of the Hypercyanotic Spell Complicating Tetralogy of Fallot
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概要
- 論文の詳細を見る
Under continuous ECG and oxygen saturation(SpO_2)monitoring, the following measurements were taken by Doppler echocardiography in 6 consecutive patients with tetralogy of Fallot(TF)before and after intravenous administration of disopyramide(2mg/kg) : left ventricular shortening fraction(LVSF) ; peak velocities in the right ventricular outflow tract(RVOT) ; diastolic and systolic internal diameters of the right ventricular outflow tract(dRVOT, sRVOT) ; and systolic blood pressure. SpO_2 increased(p<0.01)from 78 to 98(89±7, mean±standard deviation)% to 86-99(94±5)%. LVSF decreased(p<0.05)from 0.34-0.56(0.42±0.08)to 0.22-0.54(0.33±0.13). The systolic blood pressure fell slightly(p<0.05)from 68-92(79±8)to 64-92(71±11)mmHg. The sRVOT increased(p<0.05)from 2.1-4.8(2.7±1.5)mm to 3.0-8.1(4.9±2.4)mm, while RVOT peak velocity decreased(p<0.05)from 2.20-4.88(3.70±0.97)m/sec to 2.05-4.07(2.92±0.72)m/sec. Disopyramide alleviates hypoxia in patients of TF through its negative inotropic action on right ventricular outflow obstruction.
- 社団法人日本循環器学会の論文
- 1998-10-20
著者
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富田 英
Cardiovascular Center Showa University Northern Yokohama Hospital
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FUSE Shigeto
Department of Pediatrics, Sapporo Medical University School of Medicine
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TOMITA Hideshi
Department of Pediatrics, Sapporo Medical University School of Medicine
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Tomita Hideshi
昭和大学横浜市北部病院 循環器センター
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Tomita Hideshi
札幌医科大学 小児科
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Tomita Hideshi
Division Of Cardiology Showa University Northern Yokohama Hospital
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HATAKEYAMA Kinya
Hokkaido Medical Center for Child Health and Rehabilitation
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Tomita Hideshi
Department Of Materials Chemistry Faculty Of Engineering Yokohama National University
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CHIBA Shunzo
Department of Pediatrics Sapporo Medical University School of Medicine
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Fuse Shigeto
Department Of Pediatrics Sapporo Medical University Hospital
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Fuse Shigeto
Department Of Pediatrics Sapporo Medical University
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SUZUKI Masashi
Department of Geriatric Medicine, Tokyo University Hospital
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Hatakeyama Kinnya
Department of Pediatrics, Sapporo Medical University School of Medicine
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Hatakeyama Kinnya
Department Of Pediatrics Sapporo Medical University School Of Medicine
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Chiba Shunzo
Department Of Pediatrics Sapporo Medical University
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Chiba Shunzo
Department Of Pediatrics Faculty Of Medicine Sapporo Medical University
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Suzuki Masashi
Department Of Bioresources Chemistry Faculty Of Agriculture Okayama University
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Suzuki Masashi
Department Of Pediatrics Sapporo Medical University School Of Medicine
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Fuse Shigeto
Department Of Pediatrics Ntt East Sapporo Hospital
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