Disopyramide Improves Hypoxia in Patients With Tetralogy of Fallot Through a Negative Inotropic Action
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概要
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The hemodynamic and right ventricular volumetric effects of disopyramide were investigated in patients with tetralogy of Fallot(TF). Intracardiac pressure and oxygen saturation were measured, before and after intravenous administration of disopyramide(2 mg/kg)in 7 patients who had not had previous surgery. Right ventricular volume and the diameter of its outflow tract were analyzed in these 7 and in a further 4 patients with a previous shunt. Aortic oxygen saturation increased from 90.4±7.5(mean±SD)to 94.1±5.5%(p<0.05)with an increase in pulmonary blood flow and pressure. The systolic pressure gradient between the main pulmonary artery and the right ventricle decreased from 59±8 to 42±9mmHg(p<0.01). Aortic pressure fell from 77±5 to 67±4mmHg(p<0.05). Systemic vascular resistance increased from 15.3±2.2 to 19.4±3.3u・m^2(p<0.05). Pulmonary vascular resistance remained unchanged. The diastolic and systolic diameter indices of the right ventricular outflow tract increased from 17.8±3.8 to 20.5±3.4 and from 6.5±3.0 to 10.4±2.2mm/m^2, respectively(p<0.01), whereas the right ventricular ejection fraction decreased. Disopyramide improves systemic oxygen saturation in patients with TF through its negative inotropic action on the right ventricle.
- 社団法人日本循環器学会の論文
- 1999-02-20
著者
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富田 英
Cardiovascular Center Showa University Northern Yokohama Hospital
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FUSE Shigeto
Department of Pediatrics, Sapporo Medical University School of Medicine
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TAKAMURO Motoki
Department of Pediatrics, Sapporo Medical University School of Medicine
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TOMITA Hideshi
Department of Pediatrics, Sapporo Medical University School of Medicine
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Tomita Hideshi
昭和大学横浜市北部病院 循環器センター
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Tomita Hideshi
札幌医科大学 小児科
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Tomita Hideshi
Division Of Cardiology Showa University Northern Yokohama Hospital
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HATAKEYAMA Kinya
Hokkaido Medical Center for Child Health and Rehabilitation
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TAKAMURO Motoki
Hokkaido Medical Center for Child Health and Rehabilitation
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Tomita Hideshi
Department Of Materials Chemistry Faculty Of Engineering Yokohama National University
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CHIBA Shunzo
Department of Pediatrics Sapporo Medical University School of Medicine
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Fuse Shigeto
Department Of Pediatrics Sapporo Medical University Hospital
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Fuse Shigeto
Department Of Pediatrics Sapporo Medical University
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Hatakeyama Kinnya
Department of Pediatrics, Sapporo Medical University School of Medicine
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Higashidate Yoshihito
Department of Pediatric Cardiology, Hokkaido Children's Hospital and Medical Center
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Hatakeyama Kinnya
Department Of Pediatrics Sapporo Medical University School Of Medicine
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Higashidate Yoshihito
Department Of Pediatric Cardiology Hokkaido Children's Hospital And Medical Center
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Chiba Shunzo
Department Of Pediatrics Sapporo Medical University
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Takamuro Motoki
Department Of Pediatrics Sapporo Medical University School Of Medicine
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Takamuro Motoki
Department Of Pediatrics Hokkaido Medical Center For Child Health And Rehabilitation
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Chiba Shunzo
Department Of Pediatrics Faculty Of Medicine Sapporo Medical University
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Fuse Shigeto
Department Of Pediatrics Ntt East Sapporo Hospital
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