医療従事者の薬物相互作用に対する意識調査 : グレープフルーツと薬物の相互作用について

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Drug interactions broadly fall into two categories : drug-drug interactions, which occur when two or more drugs react with each other, and drug-food/beverage interactions, which occur when drugs react with a food or beverage taken concurrently. These interactions may profoundly affect drug pharmacokinetics, pharmacologic actions and efficacy, and may cause adverse reactions. To avoid the risks of drug interactions, it is important that not only medical professionals but also patients be fully aware of potential interactions, and also that consistent information be given to patients. The achievement of these two objectives can reduce the frequency of the adverse effects and improve outcomes. We selected the example of the widely discussed interactions between grapefruits and certain drugs and investigated the extent to which medical staff (doctors, nurses, dietitians, and pharmacists) were aware of them and informed their patients about them, by means of a questionnaire. From the findings, it was clear that awareness of the interactions among medical professionals varied greatly and the amount of information given to patients also varied greatly, implying that awareness of the interactions and the information provided to patients on them were both inadequate. The absence of consistent information will lead to patient confusion and is disadvantageous from a therapeutic viewpoint. We therefore believe that an important role of pharmacists' in drug therapy is to proactively provide appropriate information on drug interactions to medical professionals and patients before they have the chance to occur.
日本医療薬学会の論文
2005-12-10

医療従事者の薬物相互作用に対する意識調査 : グレープフルーツと薬物の相互作用について

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