選択的Thromboxane A_2 Synthetase Inhibitor (OKY-046)のOzone吸入後の気道過敏性に対する影響

概要

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Airway responsiveness to methacholine was measured by modified Astograph (7Hz oscillation method) before and after ozone exposure in 6 beagles, and plasma TxB_2 and histamine were measured before and after ozone exposure. There was a significant increase in airway responsiveness to methacholine after ozone exposure in the 6 beagles (p<0.05). Three out of the 6 dogs showed an apparent increase in airway responsiveness to methacholine correlating with the increase in plasma TxB_2 after ozone exposure. But there were no changes of plasma histamine after ozone exposure in any of the 6 beagles. Furthermore, the increase of airway responsiveness to methacholine and TxB_2 induced by ozone exposure was significantly inhibited by prior treatment with OKY-046 (p<0.05). From these results, it was suggested that Tx plays an important role in the development of airway hyperresponsiveness induced by ozone exposure in dogs.
日本アレルギー学会の論文
1985-07-30