アナフィラキシーに於けるBradykinin, "SRS-A"及びSubstance-Pの意義について

概要

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Dogs weighing about 10 Kg were sensitized with house serum and shocked. The change of Bradykinin and SRS-A in the blood-plasma during anaphylaxis were quantitatively determined. Bradykinin was extracted and determined following to Baraldo's method and SRS-A was determined by the method of Brocklehurst. The results show that the parallel relationship could not be observed between the doses of Bradykinin or SRA-A detected during anaphylaxis and symptoms of the shock. These results suggest that these substances may have not a significant role as the shocking agent for producing anaphylaxis. The change of substance-P in the liber and small intestine in the control and shocked guinea pigs were also quantitatively determined; but not a change was observed in the liver, though a slight increase of the amount of substance P was observed in the small intestine. From the results obtained, it might be concluded that Bradykinin, SRS-A and substance-P may have not a significant role in producing anaphylaxis.
日本アレルギー学会の論文
1961-04-30