アナフィラキシーに於けるヒスタミン遊離物質の意義について : ヒスタミン遊離物質がウサギの皮膚ヒスタミン含有量とArthus現象の発来に及ぼす影響

概要

論文の詳細を見る
Rabbits weighing 2.5 kg were actively sensitized with 2% egg-albumin in order to study the significance of histamine releaser in the mechanism of the development of Arthus phenomenon. Histamine releaser, 50γ of compound 48/80 or 500γ of sinomenin, were injected intracutaneously for 5 days successively. Extraction of histamine was done following the modified method by Dwetch and Loew and qualitatively determined by the biological technique. Results obtained indicate that the histamine content of the skin decreased to 44-71% by the treatment of compound 48/80 and 53-63% by the treatment of sinomenin. The histamine content in the same sites recovered to 79-80% 65 days after the treatment of histamine releaser and 120 days after the treatment it almost recovered to the initial level. On the other hand, histamine content in the skin developed Arthus phenomenon was observed to be increased remarkably and it was also observed that Arthus phenomenon have been developed in the skin depleted histament by the treatment of histamine releaser and histamine content in the same site of the skin was found to be increased. These facts suggest that histamine may have some relation to the development of Arthus phenomenon.
日本アレルギー学会の論文
1960-03-01