喘息における気道の閉塞のメカニズムに関する数値シミュレーション(機械力学,計測,自動制御)

概要

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A calculation model is proposed to examine generation mechanism of many lobes on inner-wall of airway in asthmatic patients and to clarify luminal occlusion of the airway inducing difficult breathing. The basement membrane in the airway wall is modeled as two-dimensional thin-walled shell having inertia force due to the mass, and smooth muscle contraction effect is replaced by uniform transmural pressure of the basement membrane. A dynamic explicit finite element method is used as a numerical simulation method. To check validity of the present model, simulation of asthma attack is performed. The number of lobes generated in the basement membrane is increased when the transmural pressure is applied in shorter time. When the remodeling of the basement membrane occurs characterized by thickening and hardening of it, it is demonstrated that the number of lobes is decreased and the occlusion of the airway lumen is progressed further. Comparison of results calculated by the present model with those measured for animal experiments of asthma will be possible.
一般社団法人日本機械学会の論文
2002-03-25