223 柔軟弾性ゲル微粒子を用いた人工/模擬血球の開発 : 粒子微粒化(OS-7 血球/生体管路の模擬)

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In this study a model blood was produced in order to use in the experiment in vitro to simulate human circulation. Real blood consists of red blood corpuscle and blood plasma. Therefore we produced alginic acid gel particles as a model blood cell, and made a dispersion agent consisting of the model blood cells and a solution of calcium chloride as a model blood. However our model blood cells had the average diameter larger than that of the real red blood corpuscles. A solution of alginic acid sodium was atomized by a nozzle, and was poured on a solution of calcium chloride to lead to a chemical reaction to form the alginic acid gel particles. In this study we tried to produce the particles that had diameters similar to that of the real red blood corpuscles(about 8.5 μm). So we tried to produce the particles by paying attention to "nozzle", "system" and "chemicals-concentration" for the purpose of atomization, and compared these new systems with the previous system with respect to the average diameter and the distribution of the particles' diameter.
2001-03-16