The Effects of Static Magnetic Fields and X-rays on Instability of Microsatellite Repetitive Sequences
スポンサーリンク
概要
- 論文の詳細を見る
To determine the genetic effect of static magnetic fields (SMF), which are not supposed to produce any significant DNA damage, we took advantage of DNA mismatch repair (MMR) deficient cells, in which all the errors produced during DNA replication are left uncorrected. We first established a simple and less labor-intensive method to analyze genetic changes in microsatellite repetitive sequences in the MMR-deficient cells. After exposure to a strong SMF (6.34T) for 24h, both MMR deficient HCT116 cells and proficient HeLa S3 cells did not exhibit any significant effect on microsatellite changes. Moreover, when HCT116 cells were synchronized at the G1/S boundary by aphidicolin and exposed to SMF during the whole S-phase, no increase in microsatellite changes was either observed. In contrast, irradiation by a low dose X-ray (2Gy) significantly increased microsatellite changes in HCT116 cells. This suggested that exposure to strong SMF may not induce any significant level of genetic changes in microsatellite sequences.
- 日本放射線影響学会の論文
著者
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石口 恒男
名古屋大学 放射線
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ISHIZAKI Kanji
Central Laboratory and Radiation Biology, Aichi Cancer Center Research Institute
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EJIMA Yosuke
Radiation Biology Center, Kyoto Univ.
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Ejima Yosuke
Radiat. Biol. Center Kyoto Univ.
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Ejima Yosuke
Radiation Biology Center Kyoto University
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石崎 寛治
Central Laboratory And Radiation Biology Aichi Cancer Center Research Institute
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Ishizaki Kanji
Central Laboratory And Radiation Biology Research Institute Aich Cancer Center
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Ishizaki K
Central Laboratory And Radiation Biology Aichi Cancer Center Research Institute
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Ishizaki Kanji
Laboratory Of Experimental Radiology Aichi Cancer Center
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ISHIGAKI Takeo
Department of Radiology, Nagoya University School of Medicine
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NAKATSUGAWA Shigekazu
Dept. Radiol., Nagoya Univ.
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NAKATSUGAWA SHIGEKAZU
Department of Radiology, Nagoya University School of Medicine
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石口 恒男
名古屋大学放射線科
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Ishizaki K
Aichi Cancer Center Research Institute
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OKUDA TAKAHITO
Laboratory of Experimental Radiology, Aichi Cancer Center
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NISHIZAWA KIMIKO
Laboratory of Experimental Radiology, Aichi Cancer Center
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Ishigaki Takeo
Department Of Radiology Nagoya City University Medical School
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Ishigaki Takeo
Dept. Radiol. Fac. Med. Nagoya Univ.
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Nishizawa Kimiko
Laboratory Of Experimental Radiology Aichi Cancer Center
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OKUDA Takahito
Dept. Radiol. , Nagoya Univ. Sch. Med.
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Nakatsugawa Shigekazu
Dept. Radiol. Nagoya Univ.
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Nakatsugawa Shigekazu
Department Of Radiology Nagoya University Hospital
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Okuda Takahito
Laboratory Of Experimental Radiology Aichi Cancer Center:department Of Radiology Nagoya University S
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Nakatsugawa Shigekazo
Dept. Radiol. Nagoya Univ. Sch. Med.
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Okuda Takahito
Laboratory Of Experimental Radiology Aichi Cancer Center:department Of Radiology Nagoya University S
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