ジカルボン酸含有リン酸八カルシウムの合成と各種側鎖基の結晶成長へ及ぼす影響

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The syntheses of octacalcium phospates (OCPs) containing dicarboxylic acids, Ca_8(HPO_4)_<2-z>(RC_2O_4)_2(PO_4)_4・mH_2O, were attempted. The effects of the side groups on crystal growth of these compounds were investigated. OCPs containing dicarboxylic acid were obtained from tricalcium phosphate (α-Ca_3(PO_4)_2) in acetic acid/sodium acetate buffer solution by hydrolysis. As for dicarboxylic acids, succinic acid, methylsuccinic acid, mercaptosuccinic acid, DL-malic acid and L-aspartic acid were used. OCPs containing dicarboxylic acid obtained in this process were determined by X-ray diffraction, scanning electron microscope, Fourier transform infrared spectrometry, thermogravimetric analyses and chemical analyses. All of these identified compounds were structurally similar to octacalcium phosphate, Ca_8(HPO_4)_2(PO_4)_4・5H_2O, with expanded α-axis unit-cell dimens ions. Phosphate ionsin "hydrated layer" of OCP were replaced by succinate ions with about 94% of theoretical replacement value. The percentage of replacement for OCPs containing dicarboxylic acid having the side groups were range 24 and 59%. Namely, the polarity and the size of the side groups effected on the incorporation of dicarboxylate ions into OCP interlamellar and the crystal growth.
2000-10-01