頭部外傷における凝固系の変動 : ウロキナーゼ抵抗試験を主として

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The purpose of this study is to report the serial changes of the coagulation activity in patients with head injuries. The coagulation activity studied included the Urokinase (UK) resistance test modified from thromboelastography, the prothrombin time (PT) and the active partial throm-boplastin time (APTT). The basic part of this study indicated that a prolongation of the UK resistance time (UKRT) reflected a decrease in the plasminogen activity due to hypercoagulability of the systemic blood and that the UKRT had no close correlation with antithrombin III. A marked prolongation of the UKRT (longer than 90 minutes under 100 I.U. UK) was found in 7 out of 16 head injury patients (7 craniotomized and 9 non-operated). The prolongation lasted for several days after the injury. On the other hand, only one of 10 controls without head injury (5 craniotomiz-ed and 5 laparotomized, all electively) showed a transient prolongation of the UKRT. In all the head injury patients, whether operated or not, the degree of the prolongation of the UKRT was grossly proportional to the clinical signs of brain damage after the injury. The prolongation of PT was observed only in the craniotomized head injury group while APTT was not specific to any groups studied. The result suggests that monitoring the UKRT after head injury is a useful and quick method for predicting the degree of brain damage and an anticoagulant therapy after head injury, though still controversial, must be considered
日本脳神経外科学会の論文
1984-10-15

頭部外傷における凝固系の変動 : ウロキナーゼ抵抗試験を主として

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