Neuron-specific enolase を用いた meningiomaの免疫組織化学的検討 : 特に正常の meningocyte との対比において

概要

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An immunohistochemical study by peroxidase-antiperoxidase method for neuron-specific enolase (NSE) was perfomed on 23 cases of (meningothelial: 10, transitional: 8, fibroblastic: 5), 3 cases of normal cranial meninx and 2 cases of choroid plexus. Meningocytes were found in the normal arachnoid membranes and choroid plexuses. These meningocytes showed positive immuno-peroxidase staining for NSE. On the other hand, dural fibroblasts showed negative staining for NSE. As for meningiomas, strongly positive immunoperoxidase stainings for NSE were seen in the meningoteclial type. Immunoperoxidase stainings for NSE were weak in the fibroblastic type. Psamrnonla bodies were found not only in the meningiomas but also in the normal tissues of the arachnoid membranes and choroid plexuses. These results and consistent with the idea that meningiomas, including meningothelial, transitional and fibroblastic types, are derived from meningocytes and not from dural fibroblasts.
日本脳神経外科学会の論文
1986-12-15