脳梗塞の形成過程:実験的,電顕的研究第一報 : 神経細胞の変化

概要

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Localized thalamic infarction was obtained in extremely high frequency utilizing our cerebral occlusion model in dogs. The ischemic cerebral tissuc of 20 dogs subjected to occlusions ranging from 15 minutes to 24 hours and immediately sacrificed thereafter, were examined by electron microscope. In the group subjected to 15-minute occlusion, no changes were observed in the nerve cells. In the 30-minute group, microvacuoles were found in the cytoplasm of some of the nerve cells in the ischemic tissue (microvacuolation). These microvacuoles were swollen mitochondria and rough endoplasmic reticulum. In the one to 3 hours group, numerous nerve cells showed shrinkage with perineuronal vacuolation. The degree of shrinkage, however, varied from severe in some to slight in others. Mitochondria, endoplasmic reticulum and ribosomal rosettes were altered in the slightly shrunken neurons. In the severely shrunken neurons the nucleus was also altered. In the 6 to 12 hours group, the number of slightly shrunken neurons decreased and the number of swollen and disrupted ones increased. Severely shrunken ones further deteriorated. In the 24 hours group, severely shrunken neurons were fragmentated and showed necrosis.
日本脳神経外科学会の論文
1979-03-15