脳室脈絡叢における酵素組織化学的研究(第4報)Mg^<2+>-ATPaseとNa^+,K^+-ATPase (p-nitrophenylphosphatase)の活性局在

概要

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To determine the ultracytochemical localization of Na^+, K^+-ATPase and Mg^<2+>-ATPase activities on normal rat choroidal epithelium, the Mayahara et al.'s one-step lead citrate method and Wachstein and Meisel's technique were employed. The electron dense reaction products which are sensitive to ouabain (10^<-3>-10^<-4>M) were observed to be abundant inside the microvilli and to be positively present along the outside of the basal plasmalemmas of the choroidal epithelium. The Mg^<2+>-ATPase activity was seen as electron dense reaction along the outside of the choroidal basal plasmalemmas. Na^+, K^+-ATPase activity is thought to be involved in cerebrospinal fluid secretion through the active movement of Na^+ in the choroidal epithelial cell. The Na^+-K^+ exchange pumps are thought to localize both in the plasmalemma of the microvilli and in the basal plasmalemmas of the choroid plexus epithelial cell.
日本脳神経外科学会の論文
1982-05-15