Neurocutaneous Melanosis Associated With Malignant Leptomeningeal Melanoma in an Adult : Clinical Significance of 5-S-Cysteinyldopa in the Cerebrospinal Fluid : Case Report

スポンサーリンク

概要

• 論文の詳細を見る

• A 35-year-old male presented with a variant of neurocutaneous melanosis with leptomeningeal malignant melanoma. He had three pigmented nevi from birth. He suffered diplopia followed by headache. T_1-weighted magnetic resonance (MR) imaging revealed hydrocephalus and a small linear hyperintense lesion in the right frontal cortex. Several parts of the cortical sulci and the brain surface were slightly enhanced by gadolinium. Ventriculoperitoneal shunting was performed and extensive pigmented leptomeninges were recognized. Open biopsy established the diagnosis of leptomeningeal malignant melanoma. Combined chemoimmunotherapy was repeated every other month with monitoring of the 5-S-cysteinyldopa (5-S-CD) level in the cerebrospinal fluid (CSF). The 5-S-CD level decreased after each treatment, but the basal level steadily increased prior to the next treatment. Two years after the onset, he showed paraplegia caused by an extramedullary mass at the T-6 level. MR imaging showed that melanoma had involved the entire subarachnoid space including the whole spine. He underwent emergent removal of the spinal tumor and showed transient marked improvement. Further intensive chemotherapy was given. However, he died 31 months after the onset of massive proliferation of intracranial leptomeningeal melanoma. Measurement of CSF 5-S-CD levels is valuable for evaluating the therapeutic efficacy and for monitoring the progression of melanoma.

• 日本脳神経外科学会の論文
• 2003-12-15

著者

• NAGAHIRO Shinji

  Departments of Neurological Surgery

• Nagahiro Shinji

  Department Of Neurosurgery Institute Of Health Biosciences The University Of Tokushima Graduate Scho

• Nagahiro Shinji

  Department Of Neurosurgery School Of Medicine The University Of Tokushima Tokushima

• Nagahiro Shinji

  Departments Of Neurological Surgery The University Of Tokushima

• UNO Masaaki

  Departments of Neurological Surgery, School of Medicine, The University of Tokushima

• SHINNO Kiyohito

  Departments of Neurological Surgery, School of Medicine, The University of Tokushima

• HORIGUCHI Hidehisa

  Departments of Pathology, School of Medicine, The University of Tokushima

• Shinno Kiyohito

  Departments Of Neurological Surgery The University Of Tokushima

• Shinno Kiyohito

  Department Of Neurosurgery National Kagawa Children's Hospital

• Uno Masaaki

  Departments Of Neurological Surgery The University Of Tokushima

• Uno Masaaki

  Department Of Neurosurgery School Of Medicine The University Of Tokushima

• Uno Masaaki

  Department Of Neurological Surgery School Of Medicine The University Of Tokushima

• Uno Masaaki

  Department Of Neurosurgery School Of Medicine University Of Tokushima

• KANNUKI Seiji

  Department of Neurosurgery, University of Tokushima School of Medicine

• Kannuki Seiji

  Departments Of Neurological Surgery The University Of Tokushima

• Kannuki Seiji

  Department Of Neurological Surgery School Of Medicine The University Of Tokushima

• NAKAISO Mami

  Departments of Neurological Surgery, The University of Tokushima

• SANO Nobuya

  Departments of Pathology, The University of Tokushima, Tokushima

• Sano Nobuya

  Departments Of Pathology The University Of Tokushima Tokushima

• Sano Nobuya

  Department Of Pathology Tokushima University Hospital

• Nakaiso Mami

  Departments Of Neurological Surgery The University Of Tokushima

• Sano N

  Department Of Mechanical And System Engineering Himeji Institute Of Technology University Of Hyogo

• Horiguchi Hidehisa

  Departments Of Pathology The University Of Tokushima Tokushima

• Horiguchi Hidehisa

  Department Of Pathology Hyogo Prefectural Awaji Hospital

• Nagahiro Shinji

  Department Of Neurosurgery Institute Of Health Biosciences The University Of Tokushima Graduate Scho

• Horiguchi H

  Department Of Electrical And Electronic Engneering Toyo University

• Horiguchi Hidehisa

  First Department Of Pathology The University Of Tokushima School Of Medicine

• Nagahiro S

  Department of Neurological Surgery, School of Medicine, The University of Tokushima

• Uno M

  Department of Neurosurgery, School of Medicine, The University of Tokushima

• Shinno K

  Departments of Neurological Surgery, The University of Tokushima

• Kannuki S

  Departments of Neurological Surgery, The University of Tokushima

• Nakaiso M

  Departments of Neurological Surgery, The University of Tokushima

関連論文

• コイル塞栓術後の脳動脈瘤手術の成績と注意点
• Anterior Ischemic Optic Neuropathy After Combined Ophthalmic Artery Embolization and Craniofacial Surgery : Case Report
• 徳島大学病院脳卒中センターにおける緊急MRI検査の適応について
• 徳島大学病院stroke centerでの脳卒中医療の現状 : 特にStroke MRIの有用性(Stroke Care Unit, Stroke Center)
• De Novo Formation and Rupture of an Intracranial Aneurysm 10 Months After Normal Findings on Conventional Magnetic Resonance Angiography in a Patient With No History of Intracranial Lesions : Case Report
• 抗血小板薬中止に伴う血小板凝集能の変化 : 脳血管障害による手術の場合
• 硬膜動静脈瘻に対する外科的治療成績とその pitfall
• 脳梗塞の3T MRI (特集 3T MRIの現状と展望)
• 無症候性頸動脈狭窄症に対する手術適応と注意点(脳血管障害におけるEBM)
• もやもや病疑診例の母親から生まれたもやもや病確診例の姉妹の1家系
• 4. 無症候性頸動脈狭窄症に対する手術適応と注意点(ES1-2 脳血管障害におけるEBMの的確な解釈と実践上の要点,イブニング教育セミナー,脳神経外科の夢と志,第28回日本脳神経外科コングレス総会)
• 頸動脈内膜剥離術 (特集 主要手術・治療とケア15)
• 術前塞栓術を併用したAVM手術(AVMの手術)
• Fiber Trackingをいかに脳神経外科手術に活用するか?(Editorial Comment)
• 2. CEAの実際と pitfall(LS1-2 内頸動脈狭窄治療の実際とピットフォール, 第27回 日本脳神経外科コングレス総会)
• 頸動脈内膜剥離術 : Evidenceに基づいたCEAの手術適応
• 診療 MRIを第一選択とした急性期脳血管障害の画像診断法
• 頭蓋外頸動脈動脈瘤に対する血行再建術
• Intracranial Cystic Hemangiopericytoma : Case Report
• Influence of Electric Field Strength in a High-Temperature Corona Discharge Reactor on Removal of Toluene from Nitrogen and Air
• Effect of Structure of Corona-Discharge Reactor on Removal of Dilute Gaseous Pollutants Using Selective Electron Attachment
• REMOVAL OF IODINE AND METHYL IODIDE IN GAS BY WETTED-WALL REACTOR BASED ON SELECTIVE ELECTRON ATTACHMENT
• Removal of Trimethylamine in Gas by Corona-Discharge Reactor
• Carotid Endarterectomy for Radiation-induced Carotid Artery Stenosis
• TP53 deleted cells in de novo glioblastomas using fluorescence in situ hybridization
• Loss of chromosome 10 in glioblastoma : Relation to proliferation and angiogenesis
• Gliosarcoma : An immunohistochemical, ultrastructural and fluorescence in situ hybridization study
• Melanocytoma of the foramen magnum
• Neonatal Brain Abscess with Intracystic Hemorrhage : Case Report
• Change of diffusion anisotropy in patients with acute cerebral infarction using statistical parametric analysis
• Effectiveness of Retrograde Perfusion of the Cerebral Vein for Attenuating Neuronal Injury After Transient Ischemia Following Reperfusion in the Rat Brain
• 頸動脈内膜剥離術の適応と手術手技
• Malignant Trigeminal Schwannoma Associated with Xeroderma Pigmentosum : Case Report
• Plasma proinflammatory and anti-inflammatory cytokine and catecholamine concentrations as predictors of neurological outcome in acute stroke patients
• Anaplastic Ganglioglioma of the Cerebellopontine Angle : Case Report
• Diffusion-Weighted and Perfusion-Weighted Magnetic Resonance Imaging to Monitor Acute Intra-arterial Thrombolysis
• Pilomyxoid Astrocytoma of the Cervical Spinal Cord Successfully Treated With Chemotherapy : Case Report
• Neurocutaneous Melanosis Associated With Malignant Leptomeningeal Melanoma in an Adult : Clinical Significance of 5-S-Cysteinyldopa in the Cerebrospinal Fluid : Case Report
• Brain Abscess and Glioblastoma Identified by Combined Proton Magnetic Resonance Spectroscopy and Diffusion-Weighted Magnetic Resonance Imaging : Two Case Reports
• Evaluation of Aneurysm Stability After Endovascular Embolization With Guglielmi Detachable Coils : Correlation Between Long-Term Stability and Volume Embolization Ratio
• Rescue Revascularization Therapy With a Stent-in-Stent Technique for Acute Intracranial Internal Carotid Artery Occlusion : Case Report
• Detection of Enlarged Cortical Vein by Magnetic Resonance Imaging Contributes to Early Diagnosis and Better Outcome for Patients With Anterior Cranial Fossa Dural Arteriovenous Fistula
• Ischemic Basilar Artery Dissecting Aneurysm Treated by Stenting Only : Case Report
• チクロピジンからクロピドグレルへの切り替えによる有効性・安全性の検討
• 3 Tesla T2^* 強調MRIで中大脳動脈内塞栓子を呈した若年性脳塞栓症の1例
• Dynamic Magnetic Resonance Appearance of the Vertebral Dissecting Aneurysm : Case Report
• Omental torsion
• Simultaneous Gas-Water Purification by a Wetted-Wall Corona Discharge Reactor : Decomposition of Aqueous Phenol and Gaseous Acetaldehyde
• Removal of Toluene from Air by Corona Discharge Reactor at High Temperature: Influence of Electric Field Strength (Proceedings of the Asia-Pacific Conference on Sustainable Energy and Environmental Technologies)
• Reversibility of Ischemic Findings on 3-T T_2^*-Weighted Imaging After Emergency Superficial Temporal Artery-Middle Cerebral Artery Anastomosis in Patients With Progressive Ischemic Stroke : Two Case Reports
• Two Different Pituitary Adenomas in a Patient with Multiple Endocrine Neoplasia Type 1 Associated with Growth Hormone-Releasing Hormone-Producing Pancreatic Tumor: Clinical and Genetic Features
• Brain tumor surgery using Niic ultrasonic surgical aspirators (NUSA)
• Formation of Crystal Film at Interface in Process of Extraction of Rare Earth Metals by D2EHPA
• Adenosarcoma of the uterine cervix presenting as a cervical polyp
• Problems in Histological Grading of Malignancy and its Clinical Significance in Patients with Operable Breast Cancer
• Growing Teratoma Syndrome in a Patient With a Non-germinomatous Germ Cell Tumor in the Neurohypophysis : Case Report
• Coexistence of Intracranial and Spinal Meningiomas : Report of Two Cases
• Surgical Management of Symptomatic Intrasellar Arachnoid Cysts : Two Case Reports
• Retinal Artery Embolization During Carotid Angioplasty and Carotid Artery Stenting : Case Report
• Pilomyxoid Astrocytoma of the Cervical Spinal Cord Successfully Treated With Chemotherapy : —Case Report—
• Non-invasive Characterization of Brain Tumor by in-vivo Proton Magnetic Resonance Spectroscopy
• Characterization of Adsorption Properties of H_2O on Si(001) and Si(111) by Ellipsometry and ab initio Molecular Orbital Calculations
• Decomposition of Aqueous Phenol by Direct Contact of Gas Corona Discharge with Water : The Influence of Current Density and Applied Voltage
• Freehand Technique for Putaminal Hemorrhage : Technical Note
• Evaluation of Initial Diffusion-weighted Image Findings in Acute Stroke Patients using a Semiquantitative Score
• 脳血管障害による不随意運動の3症例
• B-8-22 Modified A-SHD Systems for Next Generation Multimedia Networks
• Subependymoma of the spinal cord and review of the literature
• Ruptured Distal Accessory Anterior Cerebral Artery Aneurysm : Case Report
• Paraspinal Arteriovenous Fistula Presenting With Subarachnoid Hemorrhage and Acute Progressive Myelopathy : Case Report
• Microbleeds as a Prognostic Factor for Acute Subdural Hematoma
• Prediction of Cerebral Vasospasm Using Early Stage Transcranial Doppler
• Constrictive Pericarditis With Intrapericardial Abscess
• Basal Ganglia Hyperintensity on T1-weighted Imaging of a Patient with Central Nervous System Metastasis Producing Carcinoembryonic Antigens
• Acquired Pial and Dural Arteriovenous Fistulae following Superior Sagittal Sinus Thrombosis in Patients with Protein S Deficiency: A Report of Two Cases
• Constrictive Pericarditis With Intrapericardial Abscess
• Prediction of Cerebral Vasospasm Using Early Stage Transcranial Doppler

もっと見る 閉じる

スポンサーリンク