EFFECT OF NALOXONE ON HORMONAL CHANGES DURING EXERCISE
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概要
- 論文の詳細を見る
女子運動選手の月経異常発現機転において重要な要因と考えられる, スポーツ活動時のprolactin分泌亢進機構について検討した. 女子運動選手を対象とし, 月経周期の5〜8日に自転車ergometerを用いる最大運動負荷試験をnaloxone投与の有無により2回行った. naloxoneは, 運動開姶3分前に0.4mgを静注, 運動中はinfusion pumpを用い1.6mg/hrで持続投与した. 前腕静脈に翼状針を留置し, 安静臥床1時間後(Rest), 運動負荷試験中は心拍数150bpm時(Submax)と最大運動負荷時(Max), 運動終了1時間の安静臥床後(After 1hr)に採血した. 血清中prolactin, 血漿中dopamine, β-endorphin, vasoactive intestinal peptide (VIP), ACTH濃度を測定した. prolactinは, 運動負荷試験時にSubmax, Maxと著明に増加するが, naloxoneの投与により, その分泌亢進は明らかに抑制された. dopamineにはnaloxone投与の有無による差は認められなかった. しかし, β-endorphinはMax時に著明に増加するが, naloxone投与によりその上昇は明らかに抑制された. また, VIPはSubmaxおよびMaxと著明に上昇するが, naloxone投与によりこの上昇は明らかに抑制された. ACTHの運動時の上昇はnaloxone投与により抑制傾向を示した. 以上の成績より, スポーツ活動時のprolactin分泌亢進は, 内因性opioid peptidesの上昇が重要な因子として関与していることが示唆された.
- 社団法人日本産科婦人科学会の論文
- 1989-12-01
著者
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目崎 登
筑波大
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目崎 登
Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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目崎 登
Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tsukuba
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SASAKI Junichi
Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tsukuba
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MOTOBU Masaki
Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tsukuba
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NABESHIMA Yuichi
Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tsukuba
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SHOJI Makoto
Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tsukuba
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IWASAKI Hirokazu
Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tsukuba
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ASANO Katsumi
Institute of Sports and Science, University of Tsukuba
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EDA Masasuke
Institute of Sports and Science, University of Tsukuba
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Asano Katsumi
Institute Of Health And Sport Sciences University Of Tsukuba
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Shoji Makoto
Department Of Obstetrics And Gynecology Institute Of Clinical Medicine University Of Tsukuba
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Eda Masasuke
Institute Of Sports And Science University Of Tsukuba
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Motobu Masaki
Department Of Obstetrics And Gynecology Institute Of Clinical Medicine University Of Tsukuba
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Shoji Makoto
Department Of Medicine Division Of Cardiology Showa University School Of Medicine
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Nabeshima Yuichi
Department Of Obstetrics And Gynecology Institute Of Clinical Medicine University Of Tsukuba
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Iwasaki Hirokazu
Department Of Obstetrics And Gynecology Institute Of Clinical Medicine University Of Tsukuba
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Asano Katsumi
Institute Of Sports And Science University Of Tsukuba
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Sasaki Junichi
Department Of Obstetrics And Gynecology Institute Of Clinical Medicine University Of Tsukuba
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