低体重仔犬における脂肪乳剤輸注の影響第 1 報

概要

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Experimental studies were performed, for possible untoward effect and its prevention, of intravenous administration of fat emulsion (Intralipid) to low body weight puppies. Results were as follows. 1) Intralipid was given intravenously to mongrel dogs, weighing from 270g to 2, 500g, either by one shot or by drip infusion method, with doses ranging from 1.0 to 12.0g/kg. ST elevation was noted in ECG, but there were no distinct abnormal findings in blood acid-base balanse, EEG, blood pressure, pulse rate and body temperature. 2) It was found that arterial blood samples, which were taken from low body weight dogs, priorly injected with Intralipid, and incubated for 20 to 30 minutes, showed black-brownish discoloration accompanied by decrease in PO_2. This phenomenon was observed in all the experimental dogs below 1, 500 of body weight, regardless the difference of dose or mode of administration. 3) The phenomenon was manifested more markedly when incubation temperature was high (37℃) or blood sugar level was low (about 40mg/dl). When incubation temperature was very low (4℃) or blood sugar level was extremely high (about 400mg/dl), the phenomenon was not remarkable. The mechanism underlying this phenomenon is to be clarified in future, but administration of glucose, together with Intralipid, may be beneficial in treating baby patients.
日本小児外科学会の論文