:Studies on Distribution of Produced Ulcers, and on Effect of Cimetidine and Atropine

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We divined a rat's neurogenic stress ulcer model. The relative ulcer length (22.33±1.74) of the stress-ulcer model, in which 0.2ml of the arterial blood was injected intracisternally and restraint plus water-immersion for 3 hours was added, approximated the value 21.08±3.34mm which was seen, when restraint plus water-immersion for 9 hours was done in the normal rats. It was markedly higher (p<0.001) than the value 6.63±108mm of the group, in which 0.2ml of saline solution was injected intracisternally and a restraint plus water-immersion for 3 hours was added, indicating an important role played by subarachnoid hemorrhage in production of ulcers in the stress-ulcer-model. Mere intracisternal injection of blood, unaccompained by restraint plus water-immersion, did not produce ulcers. The ulcers occurred in the glandular portion of the stomach and the rumen remained intact. The highest frequency of ulcer occurrence was observed in the corpus excepting the portion of lesser curvature. Histologically, the ulcers did not extend beyond the tunica muscularis mucosae.Using the stress-ulcer-model, several counteracting measures were performed. Ulcer-inhibiting rates were as follows: cimetidine (15mg/kg) 87.5%, (30mg/kg) 85.7%, atropine sulfate (50μg/kg) 70.0%, (8mg/kg) 100%, atropine methylbromide (55μg/kg) 70.0%, combination of cimetidine (15mg/kg) and stropine sulfate (50μg/kg) 49.8%, combination of cimetidine (15mg/kg) and atropine methylbromide (55μg/kg) 34.2%, and truncal vagotomy plus pyloroplasty 97.9% (all significant at p<0.05).Ulcer-inhibiting rates on combination of cimetidine and atropine were significantly low, comparing with that of esch single drug (p<0.02).Ulcer-inhibiting rate at the antrum by administration of cimetidine 15mg/kg was significantly decreased by concomitant administration of atropine, in a small dose (either atropine sulfate 50μg/kg or atropine methylbromide 55μg/kg), and ulcer-inhibiting rate at the antrum by administration of atropine, in a small dose, was also significantly decreased by concomitant administration of cimetidine 15mg/kg (p<0.001).Effect of cimetidine 15mg/kg, or vagotomy in supperssing gastric acidity was significant (p<0.05). Effect of atropine, in a small dose, in suppressing gastric acidity was weak or lacking, and the effect of cimetidine 15mg/kg in supperssing gastice acidity was cancelled by concomitant administration of atropine, in a small dose. The possible mechanism by which the effect of cimetidine was cancelled by concomitant administration of atropine, in a small dose, was discussed.
財団法人日本消化器病学会の論文

:Studies on Distribution of Produced Ulcers, and on Effect of Cimetidine and Atropine

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