尾仙部 yolk sac 癌の1例 : 特に2〜4代培養細胞を用いた補助療法の評価と臨床経過

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A 22 month old girl of sacrococcygeal yolk carcinoma is reported. She was admitted with a painful mass in the buttock region. She died of the tumor 11 months after the admission, in spite of 2-staged operation and post-operative irradiation (10,000 rads), chemotherapy (VCR, MMC, CPA) and immunotherapy (OK-432 etc.). At autopsy, there were wide infiltration and multiple distant metastases of yolk sac carcinoma in and around the retroperitoneal space extending to the back and the pleular cavities. Such macroscopic apperances, as well as histological findings, suggested no effectiveness of radio-chemo-immunotherapy in this case. We could successfully culture the yolk sac carcinoma obtaine from the operatively resected specimen. Using the sub-cultured cells following trypsinization, we performed anti-tumor drug sensitivity test, radio-sensitivity test and cytotoxicity test by mixed lymphocyte-tumor cell cultured method. Following results were obtained. 1) Only high doses of MMC and VCR showed moderately sensitive responses. 2) After 72 hours of tissue culture following one shot irradiation of 50 to 1,400rads of 60^Co., almost all tumor cells were visible and growth rate was virtually unchanged. 3) No remarkable cytotoxicity response was noted by mixed patient's lymphocyte-tumorcell culture method. The results obtained from the studies related to tissue culture showed a significant coincidence with clinical course and autopsy findings. These clinical and laboratory results suggested that an ealier diagnosis and an ealier operation are most important for the treatment of sacrococcygeal yolk sac carcinoma. Otherwise post-operative radio-chemo-immuno-therapy might be in-effective to reduce the residual tumor or to prevent recurrence.
日本小児外科学会の論文
1980-12-20

尾仙部 yolk sac 癌の1例 : 特に2〜4代培養細胞を用いた補助療法の評価と臨床経過

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