家兎胎仔モデルを用いた先天性横隔膜ヘルニアの肺血管系に関する組織計測的研究

概要

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Diaphrgmatic hernia was experimentally produced in fetal rabbits from 21st to 25th gestational day by rup-turing the left diaphragm in utero. The pulmonary vascular system of 18 out of 48 fetuses successfully recovered was examined. Radius and thickness of the media of the pulmonary artery were measured using Suwa's histometrical techniques. Total length of the acinar arteries and capillaries were measured by stereological methods. There were no differences between models and controls in the radius of the pulmonary trunk, segmental artery, and acinar artery. The proportion of the thickness of the media to the radius increased significantly in the models, and the total length of the acinar as well as capillaries was remarkably reduced in the models. These findings were all in the bilateral lungs. These results suggest that vascular disorders caused by diaphragmatic hernia in fetal life result in absolute reduction of total pulmonary vascular capacity.
日本小児外科学会の論文
1989-02-20