VX-2 癌腫の家兎胎児及び子兎における発育について

概要

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VX-2 carcinoma cells were injected subcutaneously into the rabbit fetuses and the young rabbits. The growth of VX-2 carcinoma in rabbit fetuses was more prominent than in young rabbits, represented by the slightly larger size of tumors, higher mitotic rate, 2.2%; higher percentage of tumor cells in the tumor area, 79.8%; and the invasion into the local tissues making the entire mass fixed. In the young rabbits carcinoma was well circumscribed and abundant in the fibrous stroma. The wandering cells were prominent by found at the periphery of the tumor. The difference in the gross and microscopic findings in the fetuses and young rabbits seems to be due, at least in part, to the difference of the immunological competence of the host. It is suggested that the same phenomena, progressive growth during embryonic life and prevention of growth after birth, may occur in case with immunogenic congenital cancer.
日本小児外科学会の論文
1980-04-20