Hirschsprung 病腸管における Glial Fibrillary Acidic Protein の局在に関する免疫組織化学的研究 : S-100 Protein 陽性神経の分布との比較

概要

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The distribution of glial fibrillary acidic (GFA) protein- and S-100 protein-like immunoreactivity was studied in the colons obtained from 24 Japanese children with Hirschsprung's disease. In the enteric nervous system all supportive elements were immunoreactive to S-100 protein, and the activity was localized in the myenteric and submucous ganglia as well as in the intrinsic and extrinsic nerve fibres. On the other hand, GFA protein was present only in the subpopulation of supportive cells within extrinsic nerve fibres which were considered to be parasympathetic preganglionic fibres. We concluded that immunohistochemistry for GFA protein can be of excellent histological value in diagnosis of Hirschsprung's disease.
日本小児外科学会の論文
1988-12-20