Method of QTL Mapping in an F_2 Population using Phenotypic Means of F_3 Lines
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概要
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Mapping of quantitative trait loci (QTLs) in plants was performed using the data of marker genotypes and phenotypic values of a quantitative trait in a segregating generation such as F_2 and BC1 derived from the crossing of two pure lines. A Iarge sample must be examined to map QTLs with small effects. However genotyping of many markers for a large number of individuals is costly. For mapping QTLs using a F_2 population, useful information is included in the derived F_3 Iines. Phenotypic measurements of F_3 Iines can be obtained at a relatively low cost. Therefore, by utilizing tlhe phenotypic measurements of F_3 in addition to F_2 data, the detection of QTLs could be improved even when only a small number of F_2 individuals are genotyped. In this paper a model for mapping QTLs is proposed, where the data of both F_2 mdividuals and F_3 Iines are jointly analyzed. The effectiveness of this method is evaluated theoretically and numerically and it is shown that the ability of detecting QTL can be remarkably enhanced, especially when the heritability of the trait is low.
- 日本育種学会の論文
著者
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Ukai Yasuo
Laboratory Of Biometrics Faculty Of Agriculture The University Of Tokyo
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Ukai Yasuo
Laboratory Of Biometrics Facuty Of Agriculture The Universty Of Tokyo
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HAYASHI Takeshi
Laboratory of Biochemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Grad
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Hayashi Takeshi
National Institute Of Industrial Health
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Hayashi Takeshi
Laboratory Of Biometrics Facuty Of Agriculture The Universty Of Tokyo
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Hayashi Takeshi
Laboratory Of Animal Genetics Graduate School Of Biosphere Science Hiroshima University
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