乳幼児におけるテオフィリンクリアランスに及ぼす年齢の影響, および投与指針の検討

概要

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Theophylline clearance was investigated in 91 hospitalized children (aged 0 to 14 years) with asthma or asthmatic bronchitis, and the change in theophylline clearance with growing larger was evaluated in 12 children. The patients were administered durable intravenous of theophylline intravenously. The mean clearance in children from 0 to 1 year old was significantly decreased (P<0.01) over that in children over 2 years old, and a significant relationship between age and theophylline clearance was confirmed in children from 0 to 36 months old (r=0.647, P<0.01). The clearance was increased with growing larger in children less than 2 years old. Though, no such changes were observed in children over 2 years old. Since these data revealed that the clearance increases with growing larger in children less than 2 years old, when theophylline is to be administered to children less than 2 years old attention should be given to the effect of age on theophylline clearance. Conversely, to determine the initial optimum dosage in babies and infants, we summarize the theophylline dosage based on the above calculated regression equation, with the dosage in infants aged 6, 12, 18 and 24 months being determined to be 10.7, 12.2, 13.6 and 15.1 mg/kg/day, respectively.
日本医療薬学会の論文
1994-12-20