テオフィリン徐放性製剤 "ユニフィル錠" 投薬患者における夜間血清中テオフィリン濃度動態の検討および専用薬物動態解析ソフトの予測性の評価

概要

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Theophylline pharmacokintics at night were evaluated in 20 mild to moderate asthmatic inpatients aged 63.9±13.2 yr (mean±SD) who had been administered a once-a-day theophylline preparation "Umphyl Tablet" while the serum theophylline concentration was predicted using a pharmacokinetic analysis program designed exclusively for this preparation. The patients were administered the drug daily at 18:00 pm after dinner. Fourteen patients received a multiple dose (steady state) while six received a single dose. Blood samples to determine the serum theophylline concentration were drawn at 0 (immediately before drug administraton), and at 3, 6, 9, 12 and 15 hours after administration. Tmax was 9.6±2.4 at a steady state and 9.0±2.47 hr at a single dose state, respectively. These findings thus suggest the most suitable time of administration of this preparation to be at from 18:00 to 20:00 pm after dinner. In addition, little differnce was observed between the predictive value and observed one. The confidence of the predictive value at 3:00 and 6:00 am was high, however, the predictive value also tended to be over predictive in patients whose theophylline clearance was large.
1996-12-10