テオフィリン徐放性製剤投薬患児のコンプライアンスにおける剤型間の比較検討

概要

論文の詳細を見る
Theophylline clearance was investigated to compare patient compliance in 136 hospitalized children administered theophylline preparations for asthma or asthmatic bronchitis. The subjects were divided into four groups, that is, administered durable intravenous of theophylline intravenously group (DIV group). sustained-release theophylline granules group (Gr group), sustained-release theophylline syrup group (Syr group), and sustained-release theophylline tablet (Tab group). No differences were observed in the mean clearance between DIV. Gr, and Tab groups in children over 3 years old. However, the mean clearances of the Gr and Syr groups were increased over that of the DIV group in children less than 2 years old. Especially, the dispersion in the Syr group was increased significantly over that in the DIV group. Moreover, the dispersion of the weight of a dose taken by disposable syringe from sustained-release theophylline syrup was studied to investigate the reason why the dispersion of the clearance in Syr group was remarkably increased. Results conformed the dispersion to be markedly large. These results suggested that the mean clearance and dispersion of the Syr group were significantly increased because the dispersion was large when the syrup was taken as a dose.
日本医療薬学会の論文
1996-06-10