シプロフロキサシン注射剤と各種注射剤との配合変化

概要

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The compatibility of ciprofloxacin infusion with 85 kinds of other injections was studied in terms of the change in pH, external appearance and ciprofloxacin content. Ciprofloxacin infusion was compatible with hyperalimentation and transfusion for 24 hours under the study conditions. On the other hand, in several cases of the combination with high-pH drug products (e.g., Soldactone^<[○!R]>, Neophyllin^<[○!R]>, 5-FU^<[○!R]>, Doyle^<[○!R]>, Pansporin^<[○!R]> and Fosmicin^<[○!R]>), a change in appearance, pH and ciprofloxacin content were observed. These results showed that the ciprofloxacin content was immediately decreased when the pH value of admixture was raised in excess. of 6.0. However, the incompatibility of ciprofloxacin with Heparin sodium^<[○!R]>, Lasix^<[○!R]>. Cefoperazin^<[○!R]>, Sulperazon^<[○!R]>, Fungizone^<[○!R]>, and Bisulase^<[○!R]> was unaffected by. the pH change. The present work found that the compatibility of ciprofloxacin with other injections depended primarily on the pH value of admixtures, and that the pharmacist should avoid mixing high-pH drug products in a ciprofloxacin infusion.
日本医療薬学会の論文
1995-12-10