Relationship between Pharmaceutical Properties of Commercial Diclofenac Sodium Tablets and Plasma Concentrations in Man

概要

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Recently a large number of drugs are being marketed by various pharmaceutical companies with in fact the same active ingredient. However, the possibility remains of their varying with respect to bioavailability, since a drug's in-vitro dissolution pattern as well as its absorption rate and blood concentration follow-ing intake are greatly influenced by the formulation and process of manufacture.<BR>The present study consists of general pharmaceutical tests of four icommercial brands of diclofenac sodium as well as measurement of their plasma concentra-tions in man, followed by a discussion based on these findings concerning the relationship between their in-vitro pharmaceutical properties and bioavailability.<BR>All brands tested were found to produce almost equivalent results with respect to both contents and disintegration time, but one product did show a difference from the rest in dissolution rate along with a tendency toward slightly lower absorption in the plasma concentration test.
一般社団法人日本臨床薬理学会の論文