日本における副作用情報

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With respect to a source of adverse reaction information in Japan, publications from the Ministry of Health and Welfare, pharmaceutical manufactures, clinical researches and monographs are valuable. Since doctors, nurses, pharmacists and patients are more concerned about adverse reactions nowadays, sources of adverse reactions have rapidly been increased. To predict and cope with unexpected adverse reactions, a careful examination of case reports is important; especially an individual clinical report is extremely informative to this end, which is contrasted with the case of evaluation of drug efficacy. However, the number of the original publications is so huge, one can not look through all the information appeared. Therefore, secondary information has been used to obtain an outline of the incidence before primary information is consulted. The authors have been accumulating, for years, the cases of adverse reactions reported in clinical journals in Japan. Consequently, adverse reactions in the field of dermatology were most frequently observed and they occupied one fourth of the total incidences collected. Adverse reactions were also observed in high frequency in anesthesiology, internal medicine and psychiatry. In classification of drug action, drugs acting on the central nervous system recorded highest incidence of adverse reactions, and this was followed by antibiotics, drugs for the cardiovascular system and hormone preparations. Finally, in classification of clinical episodes caused by the drugs, eruption was most frequently observed. Other symptoms reported were abnormalities in haematopoietic function, anaphylaxies to drugs and troubles in the circulatory system.
日本医療薬学会の論文
1991-03-20

日本における副作用情報

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