20%塩化リゾチーム細粒の配合変化

概要

論文の詳細を見る
Compatibility tests of 20% lysozyme chloride fine granules with 64 other drugs were made. The mixtures wrapped in polyethylene glassine or polyethylene sheets were examined over 28 days under 3 different conditions (5±1℃, RH 45-50%; 25±2℃, RH 70-75%; 30±1℃ RH 90-92%) to check the changes in appearance and lysozyme activity. Under the 25±2℃ condition, only Resmit fine granules have proved incompatible because the mixture resulted in a color change on the 7th day of the test. This change in color resulted from the action of Resmit fine granules on lysozyme chloride fine granules, but this phenomenon did not occur under the 5±1℃ condition. We also concluded that attention must be paid when mixing this 20% lysozyme chloride fine granules with Combipenix granules, Panacid dry syrup, and Baktar granules. However, 20% lysozyme chloride fine granules, when wrapped in polyethylene, can be mixed with 35 other drugs (about 55%) even in the 30±1℃ condition. Mixtures with other drugs cannot be preserved for along period of time, primarily due to changes in appearance caused by moisture. Thus we have concluded that lysozyme chloride fine granules are a stable preparation and can be mixed with the majority of other drugs if exposure to moisture is avoided.
日本医療薬学会の論文
1984-10-20