1.5%塩化リゾチームドライシロップの配合変化(水剤の場合)

概要

論文の詳細を見る
Compatibility tests of 1.5% lysozyme chloride dry syrup with 46 other drugs in solution were made. 3 g of a lysozyme preparation was mixed with 1/2 to 1/3 of daily dose of each drug, diluted with water to 30 ml and examined over 28 days at 4 different temperatures (5±1℃,15±2℃, 25±2℃, 30±1℃) for changes in appearance, odor, redispersion and lysozyme activity. Both the Atarax-P syrup and Bisolvon syrup solutions immediately yielded nondispersive precipitates. The Inolin syrup mixture decreased to 75% in residual activity after 3 days at 15℃. Therefore, we concluded that the above-mentioned combinations are not feasible, and that attention must be paid when mixing this preparation with 7 other drugs. Most of the combinations could be preserved for 28 days at 50℃. However, in the case of suspension mixtures, the lysozyme chloride may be absorbed and cause coprecipitation, thus making it necessary to take the mixture immediately after thorough shaking.
日本医療薬学会の論文
1984-10-20