1.5%塩化リゾチームドライシロップの配合変化(散剤の場合)

概要

論文の詳細を見る
Compatibility tests of 1.5% lysozyme chloride dry syrup with 59 other drugs were made. 3g of a powdered lyozyme preparation was mixed with 1/2 to 1/3 of daily dose of each drug, and wrapped in polyethylene glassine or polyethylene sheets. Each test was continued over 28 days under 3 different conditions (5±1℃, RH 45-50%; 25±2℃, RH 70-75%; 30±1℃ RH 90-92%) to check changes in appearance and lysozyme activity. Very little change was observed in the tests made under the 25±2℃ condition, but the possibility remains that the lysozyme activity may decrease when mixed with Vibramycin dry syrup, Panacid dry syrup or Baktar Granules. Although there may be no change in appearance, care must be exercised when the lysozyme preparation is compounded with aspirin, sulpyrine and alkaline agents, because the compounds may lose their lysozyme activity.
日本医療薬学会の論文
1984-10-20