消化酵素製剤の品質比較試験 (1)

概要

論文の詳細を見る
Properties of commercial digestive enzyme capsules (Aczym, Berizym, Excelase, Feltase, Holmilase, Panatose, Politose, 7E, Stomilase, Toughmac-E) were examined. The gastric layers of the preparations were separated from the enteric cores, and their digestive activities (protease, amylase, lipase) were compared with each other. The enzyme combination ratio was also determined from weight and protease potency variation. The results were as follows : 1) The specific activities were recognized of amylase in Aczym, lipase in Berizym, Protease in Toughmac-E, and total enzyme in Politose. 2) All the preparations showed a narrow weight variation range and conformed to the provisions of J.P.IX. 3) Aczym, Excelase and Panatose had a narrow variation range of the enzyme combination ratio and were on the market as a homogeneous preparation. However, Feltase, 7E, Stomilase and Toughmac-E had a wide variation range, whereas Berizym, Holmilase and Politose showed narrow range except Some lots. In consideration of the difference among lots, we should evaluate repeatedly the quality of digestive enzyme capsule preparations at regular intervals.
日本医療薬学会の論文
1981-10-20