総合消化酵素製剤中の酵素の溶出性と安定性

概要

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Digestive activity, dissolution and stability of enzyme ingredients were compared among three commercial products (A,B and C) of multiple digestive enzyme capsules containing gastric active ingredients and enteric coated granules, respectively. Product A provides mainly gastric active enzymes with strong amylase activity. Dissolution of enzymes from enteric coated granules was observed in the acidic solution, but the rate was faster in the alkaline solution. Product B provides enzymes which maintain their activity throughout the gastrointestinal tract and has strong protease activity. Dissolution patterns of enzymes were similar to product A. Product C provides mainly enteric active enzymes with less cellulase activity. Lipase compounded in gastric active ingredients should be transferred to enteric coated granules. Enteric coated enzyme ingredients were scarcely dissolved in the acidic solution, and the dissolution rate was lower in the alkaline solution. Enzymatic activity of the three products, except lipase, were stable.
日本医療薬学会の論文