2 急性リンパ性白血病患児の唾液由来 penicillin G 耐性 Capnocytophaga の薬剤感受性とβ-lactamase活性 (第432回大阪歯科学会例会)

概要

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We compared the antibiotic sensitivity and β-lactamase activity of Capnocytophaga and Prevotella in saliva of children with infantile acute lymphatic leukemia. The minimum inhibitory concentration of β-lactam antibiotics such as penicillin G (PCG), ampicillin (ABPC), cefazolin (CEZ), cefaclor, cefmetazole, cefteram, latamoxef and aztreonam was high to PCG resistant Capnocytophaga and Prevotella. All strains tested showed resistance to β-lactam antibiotics, and had varying β-lactamase activities. The value for Capnocytophaga was 2〜33 mU/mg for ABPC and 2〜94 mU/mg for CEZ, while these figures for Prevotella were 5〜149 mU/mg and 5〜3, 135 mU/mg, respectively. Ofloxacin showed strong antibacterial activity against β-lactam antibiotic resistant organisms. These results suggest that multi-resistant strains were isolated from oral cavities of children with infantile acte lymphatic leukemia, and β-lactamase was closely related to the mechanism of β-latam antibiotic resistance in these organisms.
大阪歯科学会の論文
1994-02-25