1 学童期小児の唾液より分離したβ-lactam 剤耐性 Prevotella の β-lactamase 活性と外膜透過性 (第432回大阪歯科学会例会)

概要

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We studied the relation between the resistance to β-lactam antibiotics and β-lactamase activity, and the role of the outer membrane permeability of β-lactam antibiotic resistant Prevotella in the saliva of elementary school children. Strains which had a higher antibiotic minimum inhitory concentration (MIC) also had high β-lactamase activity. The number of strains was calculated that had both on MIC of 50 μg/ml or greater and β-lactamase activity of 30 mU/mg or more. The percentage of these strains was 17-57% for penicillin G, 0-61% for ampicillin, 50-83% for cefaclor, 0-57% for cefazolin and 0-50% for aztreonam. However, the percentages for cefmetazole, latamoxef and cefteram were low, and the value for imipenem was zero. Nine of the 58 strains tested had a cefaclor MIC with EDTA that was 1/4 or less the cefaclor MIC without EDTA. These results suggest that β-lactamase plays an important role in the mechanism of β-lactam antibiotic resistance in the Prevotella tested, and that outer membrane permeability is related to this mechanism in some of the strains.
大阪歯科学会の論文
1994-02-25