雄マウスの変異原処理によるF_1奇形と自然発生奇形

概要

論文の詳細を見る
Congenital malformations can be induced in the offspring of laboratory animals treated with a mutagen before copulation. Spectra of external malformations in offspring classified as male-mediated F_1 malformations after exposure of paternal mice to mutagens showed no evidence of a mutagen-specificity nor a germ-cell stage-dependent variation. More importantly, none of the spectra differed significantly from the type distribution of spontaneous malformations. When a teratogen was applied at the organogenic stage, embryos whose sires were preconceptually exposed to a mutagen suffered malformations with a higher frequency than those derived from untreated males. Thus, paternal exposure to mutagens can enhance susceptibility of F_1 embryos not only to spontaneous teratogenesis but also to induced malformations.
日本環境変異原学会の論文
1998-07-21