Dose and Dose-rate Effects of X rays and Fission Neutrons on Lymphocyte Apoptosis in p53(+/+) and p53(-/-) Mice
スポンサーリンク
概要
- 論文の詳細を見る
Following the exposure of mice to X rays or fission neutrons, the frequency (F) of apoptosis was measured after 4 h, and the weight loss or lymphocyte content loss in the thymus and spleen was measured after 24 h. In p53(+/+) mice, F increased linearly with the dose (D (Gy)) and the induced rate per Gy of F (detected by TUNEL staining) was 0.05 and 0.23 for X rays and fission neutrons, respectively. Therefore, the RBE of fission neutrons was 4.6 for apoptosis induction. This indicates that radiationinduced apoptosis is mostly due to double strand breaks (DSBs) in DNA because we previously obtained almost the same RBE value of fission neutrons for the induction of crossover mutations in Drosophila melanogaster, which arise from the recombinational repair of DSBs. In p53(+/+) mice, decreases in the organ weight and the lymphocyte content were observed for the thymus and the spleen 24 h after X-irradiation. These atrophic changes in the thymus and the spleen quantitatively corresponded to the total apoptotic cell deaths occurring in them. However, in p53(-/-) mice, no vigorous apoptosis was induced after X-irradiation, and hyperplastic changes in the weight and the lymphocyte content appeared in the thymus and the spleen 24 h after X-irradiation. In p53(+/+) mice, there was no difference in the induced rate per Gy of reduction in the surviving fraction of lymphocytes between acute (0.4 Gy/min) and chronic (3 mGy/min) γ irradiations. Namely, radiation-induced apoptosis in lymphocytes is a dose-rate independent event.
- 日本放射線影響学会の論文
著者
-
近藤 宗平
近畿大学・原子力研
-
伊藤 哲夫
Kinki Univ. Osaka Jpn
-
FUJIKAWA Kazuo
Department of Life Science, Faculty of Science and Technology, Kinki University
-
ITOH Tetsuo
Atomic Energy Research Institute, Kinki University
-
藤川 和男
近畿大学・原子力研
-
Fujikawa K
Department Of Life Science Faculty Of Science And Technology Kinki University
-
Fujikawa K
Kinki Univ. Higashi‐osaka Jpn
-
藤川 和男
近畿大学原子力研究所放射線生物学研究室
-
Fujikawa K
Faculty Of Science And Engineering Kinki University
-
FUJIKAWA Kazuo
Atomic Energy Res. Inst. Kinki Univ.
-
KONDO Sohei
Atomic Energy Res. Inst. Kinki Univ.
-
Itoh Tetsuo
Atomic Energy Research Institute Kinki University
-
Kondo Sohei
Atomic E. Res. Inst. Kinki Univ.
-
HASEGAWA YUKINORI
Atomic Energy Research Institute, Kinki University
-
MATSUZAWA SHINYA
Atomic Energy Research Institute, Kinki University
-
FUKUNAGA AKIHIRO
Osaka City University College of Nursing
-
Matsuzawa Shinya
Atomic Energy Research Institute Kinki University
-
Hasegawa Yukinori
Atomic Energy Research Institute Kinki University
-
Fukunaga A
Osaka City University College Of Nursing
-
伊藤 哲夫[他]
近畿大学原子力研究所
関連論文
- 熱中性子用位置感応型比例計数管における位置ピーク分裂現象
- 催奇性障害防御におけるp53 dependent apoptosisの役割
- Comparative Susceptibility of a Wild Derived Strain of Mus musculus molossinus and Laboratory Mice to Teratogenesis by Ethylnitrosourea
- 近畿大学原子炉45年の歩みと今後の役割
- Microdosimetry on a Mini-Reactor UTR-KINKI for Educational Uses and Biological Researches
- 日本保健物理学会第43回研究発表会を開催して
- 関西地区における自然放射線測定 ―環境要因・測定条件との関連に着目して―
- 材料物性を活用した超長期自記環境記録装置[千年時計]の開発 : 背景と基本方針
- 核分裂中性子あるいはX線によって一年生キク科植物ハプロパップス種子で誘発された体細胞染色体変異の成長過程での消長
- 核分裂中性子とX線による一年生キク科植物ハプロパップスの発芽種子根端分裂細胞における小核形成
- Neutronic Calculations for Modification of Kinki University Reactor from HEU to LEU Fuels
- 近畿大学炉における天然ウラン体系の臨界実験 (I)
- 近畿大学炉を用いた標準的1/Eスペクトル中性子場における (51)^V,(58)^Fe,(181)^Ta,(186)^W の共鳴積分の測定
- 近畿大学炉の内部黒鉛反射体におけるボイド反応度の測定
- 近畿大学炉における原子炉運転特性の計算機によるデータ集録と解析 (II)
- 近畿大学炉におけるトリウム体系の臨界実験と解析
- 放射線管理
- 放射線管理
- 放射線管理
- 落下法による制御棒等価反応度測定における検出器位置依存性、隣接制御棒干渉効果および燃料装荷分布の影響
- 放射線管理
- 原子炉施設の放射線管理設備の更新と試験検査結果
- O2-05 幹細胞突然変異の放射線による誘発と線量率効果 : マウスDLbテストによる検討
- ML-3 アポトーシス組織修復
- 放射線リスクにしきい値がある科学的証拠
- アメリカの新しい波「放射線, 科学, 健康協会」 Radiation, Science, and Health, (RSH)Inc.
- 米国の新しい波「放射線, 科学, 健康」協会
- 黎明期の思い出
- 自爆遺伝子の世界 (第12回産業医科大学学会総会学術講演会記録)
- Apoptosis by Antitumor Agents and Other Factors in Relation to Cell Cycle Checkpoints
- Rational Risk Estimation in Relation to Atomic Bomb Radiation
- 雄マウスの変異原処理によるF_1奇形と自然発生奇形
- Modified Susceptibility to Teratogenesis in the Offspring of Male Mice Exposed to Mutagens
- Frequency and Type of Malformations in the Offspring of C57BL/6 Male Mice Treated with Ethylnitrosourea
- Resistance of Murine Fetuses to Mutation Induction by X-rays at the Dlb-1 Locus in the Small Intestine
- The RBE of fast neutrons for induction of apoptosis in murine thymus is 4
- Radiation hormesis and teratogenesis in soybean
- Radiation-induced apoptosis in embryos of Drosophila
- 自爆遺伝子の世界
- 遺伝子は変わるべくして変わる--がん化と進化の接点
- 寿命はプログラムされている(特別講演) (第15回日本老年学会総会記録)
- 癌研究の最前線-20-ショウジョウバエを用いた発癌研究
- 老化-3-進化と寿命
- Energy-dependent RBE of Neutrons to Induce Micronuclei in Root-tip Cells of Allium cepa Onion Irradiated as Dry Dormant Seeds and Seedlings
- Neural Networks for the Neutron Spectrum Determination Based on the Foil Activation Method
- p53-dependent Apoptosis Suppresses Radiation-induced Teratogenesis
- p53-dependent Apoptosis is Required for a Complete Repair of Teratogenic Damage
- Relationship between p53 protein and Radiation-Induced Apoptosis in Embryo
- p53-dependent apoptosis for defense against radiation-induced teratogenesis
- D2-06 放射線照射によるイエギクの突然変異の実例と教材化
- D2-05 カイワレダイコンの発芽種子の成長に及ぼすX線照射の影響
- Role of p53 Gene for Radiation-Induced Teratogenesis at Low Dose-Rate
- P068 マウス小腸幹細胞におけるDlb-1座のX線によって誘発される突然変異の持続性及び蓄積性(ポスターセッション)
- Critical Experiments and Analysis on Thorium and Natural Uranium Test Assemblies in UTR-KINKI
- 臨床と解剖セミナ--110完-細胞の癌化をめぐって
- Residential Radon Exposure and Lung Cancer Risk in Misasa, Japan: a Case-control Study
- Mortality and Cancer Incidence in Misasa, Japan, a Spa Area with Elevated Radon Levels
- Dose and Dose-rate Effects of X rays and Fission Neutrons on Lymphocyte Apoptosis in p53(+/+) and p53(-/-) Mice
- Suppression of genotoxicity of X-rays in somatic cells of Drosophila melanogaster by (-)-epigallocatechin gallate, (-)-epigallocatechin, and theaflavin digallate
- ダイオキシンの継世代催奇性 : 第10回公開シンポジウム : 内分泌撹乱物質の作用機序と後世代影響 : 環境変異原研究との接点
- 放射線奇形の分子機構研究のためのショウジョウバエ実験系の開発
- ショウジョウバエ卵母細胞のガス環境と染色体不分離
- Repetitious Production of Similar Karyotypes in Different Plants of Haplopappus gracilis, an Annual Asteraceae, Following Exposure to Ionizing Radiation
- Induction of multi-karyotypes and genome stability in Zebrina pendula (2n=23) after irradiation of X-rays
- Neutron spectra determination from activated specific activities using neural network technique
- Dose Estimations of Fast Neutrons from a Nuclear Reactor by Micronuclear Yields in Onion Seedlings
- P-2(O-10)Frequency patterns of micronuclei induced in Allium cepa seedlings by physical and chemical agents
- Dosimetry of Mixed Neutron and Gamma Radiation with Paired Fricke Solutions in Light and Heavy Water
- 幼若細胞の突然変異標識による大豆の葉原基の発生の追跡〔英文〕
- I. Evidence That There are Threshold Effects in Risk of Radiation
- Aneuploids produced in the offspring of DTiosophila melanogaster femaies exposed to carbon dioxide
- 実験実習とインターネット遠隔実習を組み合わせた原子炉教育の体系化
- Marked Changes in Susceptibility of Drosophila melanogaster Embryos to Killing and Malformations with Time of X-Irradiation
- Evidence that There are Threshold Effects in Risk from Radiation Carcinogenesis
- 遺伝子導入ショウジョウバエで過剰発現したDNAポリメラ-ゼβのDNA修復と組み換えに及ぼす影響〔英文〕
- Development of a micronucleus assay in the root tips of Allium cepa seedlings as a detector of chemical clastogens
- 大豆Xantha類似遺伝子の体細胞復帰変異の速中性子とX線による誘発〔英文〕
- 福島第一原発事故に起因する放射性物質による生活環境における土壌汚染に関する調査
- Humans are well buffered against toxicity from low-level radiation
- 〈報告〉福島第一原子力発電所事故後に実施した一般向け電話相談
- 福島第一原子力発電所事故後に実施した一般向け電話相談
- Health effects of low-level radiation : Recent progress in radiation life science
- Tissue Misrepair Hypothesis for Radiation Carcinogenesis